In the framework of our studies dealing with the development of new platforms for the delivery of antiviral agents, we exploited the covalent approach based on click chemistry to link β-cyclodextrin (CD) on hyaluronic acid backbone (HA). The physico-chemical properties in terms of size, surface charge, interaction with acyclovir (Acy), selected as a model antiviral drug, have been investigated. The release profile and the biological properties (cytotoxicity and inhibition of viral plaque formation) of HA-CD/Acy complex pointed out a good antiviral activity together with a delayed-release of Acy from HA-CD/Acy.
File in questo prodotto:
Non ci sono file associati a questo prodotto.