gd T cells are believed to play a critical role in linking innate and acquired immunity. They produce INF-g, a cytokine of the T helper 1 pathway that has a protective activity in HIV disease progression [1]. gd T cells are generally CD4 and CD8 negative, produce large amounts of cytokines on activation, and recognize phosphorilated nonpeptidic antigens in a major histocompatibility complex–unrestricted manner. As such, they do not require antigen-presenting cell processing and presentation [1]. Furthermore, these cells are reactive against Mycobacterium tuberculosis, intracellular pathogens, and HIV. In vitro, Vg2Vd2 T cells have been shown to posses diverse anti-HIV activities
Do Vgamma2Vdelta2 T cells influence HIV disease progression?
NUNNARI G
2008-01-01
Abstract
gd T cells are believed to play a critical role in linking innate and acquired immunity. They produce INF-g, a cytokine of the T helper 1 pathway that has a protective activity in HIV disease progression [1]. gd T cells are generally CD4 and CD8 negative, produce large amounts of cytokines on activation, and recognize phosphorilated nonpeptidic antigens in a major histocompatibility complex–unrestricted manner. As such, they do not require antigen-presenting cell processing and presentation [1]. Furthermore, these cells are reactive against Mycobacterium tuberculosis, intracellular pathogens, and HIV. In vitro, Vg2Vd2 T cells have been shown to posses diverse anti-HIV activitiesPubblicazioni consigliate
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