Curcumin and genistein are two natural products obtained from Curcuma longa L. and soybeans, endowed with many biological properties. Within the last years they were shown to possess also a promising antitrypanosomal activity. In the present paper, we investigated the activity of both curcumin and genistein against rhodesain, the main cysteine protease of Trypanosoma brucei rhodesiense; drug combination studies, according to Chou and Talalay method, allowed us to demonstrate a potent synergistic effect for the combination curcumin-genistein. As a matter of fact, with our experiments we observed that the combination index of curcumingenistein is < 1 for the reduction from 10 to 90% of rhodesain activity.

Drug combination studies of curcumin and genistein against rhodesain of Trypanosoma brucei rhodesiense

Roberta Ettari
Primo
;
Santo Previti;Santina Maiorana;Alessandro Allegra;Silvana Grasso;Maria Zappalà
Ultimo
2019

Abstract

Curcumin and genistein are two natural products obtained from Curcuma longa L. and soybeans, endowed with many biological properties. Within the last years they were shown to possess also a promising antitrypanosomal activity. In the present paper, we investigated the activity of both curcumin and genistein against rhodesain, the main cysteine protease of Trypanosoma brucei rhodesiense; drug combination studies, according to Chou and Talalay method, allowed us to demonstrate a potent synergistic effect for the combination curcumin-genistein. As a matter of fact, with our experiments we observed that the combination index of curcumingenistein is < 1 for the reduction from 10 to 90% of rhodesain activity.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11570/3134367
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