Curcumin and genistein are two natural products obtained from Curcuma longa L. and soybeans, endowed with many biological properties. Within the last years they were shown to possess also a promising antitrypanosomal activity. In the present paper, we investigated the activity of both curcumin and genistein against rhodesain, the main cysteine protease of Trypanosoma brucei rhodesiense; drug combination studies, according to Chou and Talalay method, allowed us to demonstrate a potent synergistic effect for the combination curcumin-genistein. As a matter of fact, with our experiments we observed that the combination index of curcumingenistein is < 1 for the reduction from 10 to 90% of rhodesain activity.
Drug combination studies of curcumin and genistein against rhodesain of Trypanosoma brucei rhodesiense
Roberta Ettari
Primo
;Santo Previti;Santina Maiorana;Alessandro Allegra;Silvana Grasso;Maria ZappalàUltimo
2019-01-01
Abstract
Curcumin and genistein are two natural products obtained from Curcuma longa L. and soybeans, endowed with many biological properties. Within the last years they were shown to possess also a promising antitrypanosomal activity. In the present paper, we investigated the activity of both curcumin and genistein against rhodesain, the main cysteine protease of Trypanosoma brucei rhodesiense; drug combination studies, according to Chou and Talalay method, allowed us to demonstrate a potent synergistic effect for the combination curcumin-genistein. As a matter of fact, with our experiments we observed that the combination index of curcumingenistein is < 1 for the reduction from 10 to 90% of rhodesain activity.File | Dimensione | Formato | |
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