Multiple Sclerosis (MS) is an autoimmune demyelinating disease of the central nervous system (CNS), mainly mediated by Th1 and/or Th17 cells. Recent evidence indicates that Th2 cells and mast cells (MCs), are also involved. Brain MCs in MS are activated by neural factors, which induce release of several inflammatory mediators. Interleukin (IL)-31 is a novel T helper (Th) 2 cytokine produced by human MCs. We evaluated IL-31 serum concentration in a MS patient and in 18 healthy controls. IL-31 serum levels were markedly higher than in the control group (62.306 pg/ml vs. 7.623 ± 7.681 pg/ml). This suggests a possible role for elevated IL-31 levels in pathogenesis of MS.
Increased serum levels of interleukin-31 could modulate inflammatory processes in multiple sclerosis
GANGEMI, Sebastiano;ALLEGRA, Alessandro;MANNUCCI, CARMEN;ALONCI, Andrea;Calapai, F.;MUSOLINO, Caterina
2013-01-01
Abstract
Multiple Sclerosis (MS) is an autoimmune demyelinating disease of the central nervous system (CNS), mainly mediated by Th1 and/or Th17 cells. Recent evidence indicates that Th2 cells and mast cells (MCs), are also involved. Brain MCs in MS are activated by neural factors, which induce release of several inflammatory mediators. Interleukin (IL)-31 is a novel T helper (Th) 2 cytokine produced by human MCs. We evaluated IL-31 serum concentration in a MS patient and in 18 healthy controls. IL-31 serum levels were markedly higher than in the control group (62.306 pg/ml vs. 7.623 ± 7.681 pg/ml). This suggests a possible role for elevated IL-31 levels in pathogenesis of MS.Pubblicazioni consigliate
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