Vascular dementia and aliamides: A new approach for the future

Vascular dementia (VaD) is the first usual cases of dementia after Alzheimer's disease, causing approximately 15% of instances. Yet, unlike Alzheimer's disease, there are no treatments to diminish the inflammatory process correlated to vascular dementia. Palmitoylethanolamide (PEA) was discovered more than five decenniums ago and has been proved to counteract peripheral inflammation and mast-cell degranulation, as good as to exert neuroprotective and antinociceptive effects in rats and mice experimental model. Luteolin (Lut) is an important flavone that has advantageous neuroprotective impacts both in vitro and in vivo. This mini-review gives a little outline of current information of PEA and Luteolin impact on various experimental model and the novel possible PEA-Lut use for the treatment of VaD.