We investigated the anatomical correlates of chronic unilateral neglect in right brain damaged patients with no visual field defects. Independently from basal ganglia or thalamus involvement, neglect patients had a subcortical area of maximal lesion overlap (maxov) in the superior longitudinal fasciculus (SLF). Neglect patients without lesion of subcortical nuclei had an additional maxov area in the rostralmost limit of the supramarginal gyrus (SmG). Patients without neglect showed a maxov area in the corticospinal tract with no involvement of the SLF or SmG. These findings call attention to the role of parietal-frontal disconnection in the pathogenesis of neglect. This disconnection can make neglect generalised and enduring also in patients suffering only partial damage of the parietal-temporal cortex, and who would otherwise show more selective attentional impairments.

The anatomy of neglect without hemianopia: a key role for parietal-frontal disconnection?

Tomaiuolo, Francesco
2003

Abstract

We investigated the anatomical correlates of chronic unilateral neglect in right brain damaged patients with no visual field defects. Independently from basal ganglia or thalamus involvement, neglect patients had a subcortical area of maximal lesion overlap (maxov) in the superior longitudinal fasciculus (SLF). Neglect patients without lesion of subcortical nuclei had an additional maxov area in the rostralmost limit of the supramarginal gyrus (SmG). Patients without neglect showed a maxov area in the corticospinal tract with no involvement of the SLF or SmG. These findings call attention to the role of parietal-frontal disconnection in the pathogenesis of neglect. This disconnection can make neglect generalised and enduring also in patients suffering only partial damage of the parietal-temporal cortex, and who would otherwise show more selective attentional impairments.
File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11570/3145861
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? 66
  • Scopus 185
  • ???jsp.display-item.citation.isi??? 197
social impact