Prospective Review of Clinical Hypersensitivity Reactions After Administration of 5% Human Serum Albumin in 40 Critically Ill Cats

This prospective study assesses the presence of immediate and delayed clinical hypersensitivity reactions in 40 hypoalbuminemic critically ill cats during and after an intravenous administration of 5% human serum albumin (HSA). Twenty hypoalbuminemic critically ill cats with no known exposure to HSA (control group) were also checked in order to highlight any clinical signs related to the underlying disease which could mimic hypersensitivity reactions. The administration of 10-20 mL/kg of 5% HSA at 2 mL/kg/h in critically ill cats did not lead to clinical signs of types I and III hypersensitivity reactions at days 0, 7, 14, 21, and 28, unlike previous findings with 25% HSA in this species.