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EnglishPapillary thyroid carcinoma (PTC) is a heterogeneous group with differing pathogenesis and prognosis of the individual subtypes. In addition, a tumor entity has been spun off, now referred to as "noninvasive follicular neoplasm with papillary-like nuclear features (NIFTP). A recent study, based on a comprenhensive evaluation of a prospective multicenter NIFTP-based retrospective study, was intended to clarify whether NIFTP can metastasize and thus justify a reduced resection rate compared to classical PTC. For 3 reasons, Authors nicely recommend caution regarding a limited thyroid procedure (i.e lobectomy vs. completion thyroidectomy): i) in the current literature, lymph node metastase have benn described in 10 patients with NIFTP, and in 1 patient lung metastases. ii) As reported for the first time in this study, nearly one-fifth of patients have NIFTP-associated PTMC with unclear potential for metastasis. iii) Observation periods are still relatively short and so far, there are no agreed follow-up standards.
| Titolo: | Recommended Surgery for >1 cm Noninvasive Follicular Neoplasia with Papillary-Like Nuclear Features (NIFTP) |
| Autori: | DIONIGI, Gianlorenzo (Ultimo) |
| Data di pubblicazione: | 2019 |
| Rivista: | |
| Abstract: | Papillary thyroid carcinoma (PTC) is a heterogeneous group with differing pathogenesis and prognosis of the individual subtypes. In addition, a tumor entity has been spun off, now referred to as "noninvasive follicular neoplasm with papillary-like nuclear features (NIFTP). A recent study, based on a comprenhensive evaluation of a prospective multicenter NIFTP-based retrospective study, was intended to clarify whether NIFTP can metastasize and thus justify a reduced resection rate compared to classical PTC. For 3 reasons, Authors nicely recommend caution regarding a limited thyroid procedure (i.e lobectomy vs. completion thyroidectomy): i) in the current literature, lymph node metastase have benn described in 10 patients with NIFTP, and in 1 patient lung metastases. ii) As reported for the first time in this study, nearly one-fifth of patients have NIFTP-associated PTMC with unclear potential for metastasis. iii) Observation periods are still relatively short and so far, there are no agreed follow-up standards. |
| Handle: | http://hdl.handle.net/11570/3147390 |
| Appare nelle tipologie: | 14.a.1 Articolo su rivista |
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| File | Descrizione | Tipologia | Licenza | |
|---|---|---|---|---|
| 3147390.pdf | Versione Editoriale (PDF) |  | Open Access Visualizza/Apri |
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