The present study tested if the addition of butorphanol to medetomidine-isoflurane anaesthesia reduces isoflurane requirements and assessed cardiopulmonary function and recovery quality. Horses undergoing elective surgery were sedated with medetomidine (7 μg kg-1); anaesthesia was induced with ketamine (2.2 mg kg-1) and diazepam (0.02 mg kg-1) and maintained with isoflurane and a CRI of medetomidine (3.5 μg kg-1 h-1). In a randomised blinded fashion horses received butorphanol (group BM) (25 μg kg-1 bolus followed by 25 μg kg-1 hour-1) or an equal volume of saline (group M). Horses were artificially ventilated, received ringers lactate 5 ml kg-1hour-1and dobutamine < 1.25 μg kg-1 minute-1. Composition of in- and exhaled gases, heart rate and mean arterial blood pressures (MAP) were continuously monitored; pH and arterial blood gases were measured every 30 minutes. Recovery was timed and scored with a numerical rating scale (1 = best – 5 = worst). Data were analyzed using two way RM-ANOVA, independent t-tests or mann-whitney rank sum test (p < 0.05) as appropriate. Data were analysed from 61 horses (MB 31, M 30). Data are presented as mean ± SD or median, range. There was no difference between the groups in anaesthesia duration (MB: 115, 55-230, M: 104, 66-230 minutes ), end-tidal isoflurane (MB: 1.06± 0.11, M: 1.05 ± 0.1 %), MAP (MB: 88 ± 9, M: 87 ± 7 mmHg), heart rates (MB: 33 ± 6, M: 35 ± 8 bpm), pH (MB: 7.37 ± 0.03, M: 7.38 ± 0.03), PaO2 (MB: 19.2 ± 6.6, M: 18.2 ± 6.6 kPa), PaCO2 (MB: 6.9 ± 0.6, M:6.7 ± 0.7 kPa). Recovery was not different between the groups, however time to extubation was longer with MB (26.9 ±10.9 minutes) than M (20.4 ± 9.4 minutes). Butorphanol does not decrease isoflurane requirements in horses anaesthetised with medetomidine-isoflurane and has no influence on cardiopulmonary function or recovery.
A clinical study on the effect in horses during medetomidine-isoflurane anaesthesia,of butorphanol constant rate infusion on isoflurane requirements, on cardiopulmonary function and on recovery characteristics
Vullo C;
2011-01-01
Abstract
The present study tested if the addition of butorphanol to medetomidine-isoflurane anaesthesia reduces isoflurane requirements and assessed cardiopulmonary function and recovery quality. Horses undergoing elective surgery were sedated with medetomidine (7 μg kg-1); anaesthesia was induced with ketamine (2.2 mg kg-1) and diazepam (0.02 mg kg-1) and maintained with isoflurane and a CRI of medetomidine (3.5 μg kg-1 h-1). In a randomised blinded fashion horses received butorphanol (group BM) (25 μg kg-1 bolus followed by 25 μg kg-1 hour-1) or an equal volume of saline (group M). Horses were artificially ventilated, received ringers lactate 5 ml kg-1hour-1and dobutamine < 1.25 μg kg-1 minute-1. Composition of in- and exhaled gases, heart rate and mean arterial blood pressures (MAP) were continuously monitored; pH and arterial blood gases were measured every 30 minutes. Recovery was timed and scored with a numerical rating scale (1 = best – 5 = worst). Data were analyzed using two way RM-ANOVA, independent t-tests or mann-whitney rank sum test (p < 0.05) as appropriate. Data were analysed from 61 horses (MB 31, M 30). Data are presented as mean ± SD or median, range. There was no difference between the groups in anaesthesia duration (MB: 115, 55-230, M: 104, 66-230 minutes ), end-tidal isoflurane (MB: 1.06± 0.11, M: 1.05 ± 0.1 %), MAP (MB: 88 ± 9, M: 87 ± 7 mmHg), heart rates (MB: 33 ± 6, M: 35 ± 8 bpm), pH (MB: 7.37 ± 0.03, M: 7.38 ± 0.03), PaO2 (MB: 19.2 ± 6.6, M: 18.2 ± 6.6 kPa), PaCO2 (MB: 6.9 ± 0.6, M:6.7 ± 0.7 kPa). Recovery was not different between the groups, however time to extubation was longer with MB (26.9 ±10.9 minutes) than M (20.4 ± 9.4 minutes). Butorphanol does not decrease isoflurane requirements in horses anaesthetised with medetomidine-isoflurane and has no influence on cardiopulmonary function or recovery.Pubblicazioni consigliate
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