The activity of the hypothalamic-pituitary-adrenal (HPA) axis is commonly dysregulated in stress-related psychiatric disorders. Annexin A1 (ANXA1), an endogenous ligand of formyl peptide receptor (FPR) 2/3, is a member of the family of phospholipid- and calcium-binding proteins with a well-defined role in the delayed early inhibitory feedback of glucocorticoids (GC) in the pituitary gland and implicated in the occurrence of behavioural disorders such as anxiety.
The role of Annexin A1 and formyl peptide receptor 2/3 signaling on chronic corticosterone-induced depression-like behaviors and impairment in hippocampal-dependent memory
Peritore, Alessio Filippo;Crupi, Rosalia;Gugliandolo, Enrico;Siracusa, Rosalba;Impellizzeri, Daniela;Cordaro, Marika;D'amico, Ramona;Fusco, Roberta;Di Paola, Rosanna;Cuzzocrea, Salvatore
2020-01-01
Abstract
The activity of the hypothalamic-pituitary-adrenal (HPA) axis is commonly dysregulated in stress-related psychiatric disorders. Annexin A1 (ANXA1), an endogenous ligand of formyl peptide receptor (FPR) 2/3, is a member of the family of phospholipid- and calcium-binding proteins with a well-defined role in the delayed early inhibitory feedback of glucocorticoids (GC) in the pituitary gland and implicated in the occurrence of behavioural disorders such as anxiety.File in questo prodotto:
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