The activity of the hypothalamic-pituitary-adrenal (HPA) axis is commonly dysregulated in stress-related psychiatric disorders. Annexin A1 (ANXA1), an endogenous ligand of formyl peptide receptor (FPR) 2/3, is a member of the family of phospholipid- and calcium-binding proteins with a well-defined role in the delayed early inhibitory feedback of glucocorticoids (GC) in the pituitary gland and implicated in the occurrence of behavioural disorders such as anxiety.

The role of Annexin A1 and formyl peptide receptor 2/3 signaling on chronic corticosterone-induced depression-like behaviors and impairment in hippocampal-dependent memory

Peritore, Alessio Filippo;Crupi, Rosalia;Gugliandolo, Enrico;Siracusa, Rosalba;Impellizzeri, Daniela;Cordaro, Marika;D'amico, Ramona;Fusco, Roberta;Di Paola, Rosanna;Cuzzocrea, Salvatore
2020-01-01

Abstract

The activity of the hypothalamic-pituitary-adrenal (HPA) axis is commonly dysregulated in stress-related psychiatric disorders. Annexin A1 (ANXA1), an endogenous ligand of formyl peptide receptor (FPR) 2/3, is a member of the family of phospholipid- and calcium-binding proteins with a well-defined role in the delayed early inhibitory feedback of glucocorticoids (GC) in the pituitary gland and implicated in the occurrence of behavioural disorders such as anxiety.
2020
File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11570/3160419
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? 37
  • Scopus 42
  • ???jsp.display-item.citation.isi??? 41
social impact