Several studies demonstrated that hyperpigmentation pathologies might be treated by using agents targeting the enzymatic metallo-protein tyrosinase. Therefore, we predicted the development of a series of small molecules able to inhibit diphenolase activity of tyrosinase from Agaricus bisporus. The designed compounds were readily synthesized by S-alkylation and the synthesized compounds were tested through biochemical screening, thus providing structure-affinity relationships for this class of 5-(pyridin-4-yl)-3-(alkylsulfanyl)-4H- 1,2,4-triazol-4-amine derivatives. In addition, docking simulations suggested the binding mode within the catalytic site of the targeted enzyme
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