Impact of pharmaceutical products on zebrafish: an effective tool to assess aquatic pollution

Overuse of pharmaceuticals products (PPs) and sometimes ineffective wastewater purification systems have led to the accumulation of these residues in aquatic systems. Raising concerns about the likely harmful effects of these substances both to ecosystems and to human health. Animals as model organisms are nowadays increasingly used to track the health of environmental system around the world. They can be used to understand biological processes, to obtain information on the health status of the environment, and to better understand the effects of xenobiotics on organisms. Among model organisms, the zebrafish (Danio rerio) is one of the best models for studying evolution biology, cancer, toxicology, drug discovery, and genetics. This fish is a multipurpose model organism, due to its easy of maintenance and keeping and the transparency of the embryo during the early stages of development. In this paper, the toxicological effects of typical PPs, and their effects on zebrafish are reviewed. Many PPs have been found to be toxic or even fatal to zebrafish. Showing how these pharmaceuticals compound can affect zebrafish from the larval stage and even in the adult stage. Zebrafish is thus a model for how we can better understand how medications affect not only individual fish but the entire aquatic ecosystem, bringing about perturbations in their behaviour and putting their survival at risk.