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Rationale & Objective: It is unclear whether the effect of canagliflozin on adverse kidney and cardiovascular events in those with diabetic kid-ney disease varies by age and sex. We assessed the effects of canagliflozin among age group categories and between sexes in the Canagli-flozin and Renal Endpoints in Diabetes with Established Nephropathy Clinical Evaluation (CREDENCE) study.Study Design: Secondary analysis of a random-ized controlled trial. Setting & Participants: Participants in the CREDENCE trial. Intervention: Participants were randomly assigned to receive canagliflozin 100 mg/d or placebo.Outcomes: Primary composite outcome of kid-ney failure, doubling of serum creatinine con-centration, or death due to kidney or cardiovascular disease. Prespecified secondary and safety outcomes were also analyzed. Out-comes were evaluated by age at baseline (<60, 60-69, and >_70 years) and sex in the intention-to-treat population using Cox regression models.Results: The mean age of the cohort was 63.0 & PLUSMN; 9.2 years, and 34% were female. Older age and female sex were independently associ-ated with a lower risk of the composite of adverse kidney outcomes. There was no evidence that the effect of canagliflozin on the primary outcome (acomposite of kidney failure, a doubling of serum creatinine concentration, or death from kidney or cardiovascular causes) differed between age groups (HRs, 0.67 [95% CI, 0.52-0.87], 0.63 [0.4 8-0.82], and 0.89 [0.61-1.29] for ages <60, 60-69, and >_70 years, respectively; P = 0.3 for interaction) or sexes (HRs, 0.71 [95% CI, 0.5 4-0.95] and 0.69 [0.56-0.8 4] in women and men, respectively; P = 0.8 for interaction). No differences in safety outcomes by age group or sex were observed.Limitations: This was a post hoc analysis with multiple comparisons.Conclusions: Canagliflozin consistently reduced the relative risk of kidney events in people with diabetic kidney disease in both sexes and across age subgroups. As a result of greater background risk, the absolute reduction in adverse kidney outcomes was greater in younger participants.Funding: This post hoc analysis of the CREDENCE trial was not funded. The CREDENCE study was sponsored by Janssen Research and Development and was conducted collaboratively by the sponsor, an academic-led steering committee, and an academic research organization, George Clinical.Trial Registration: The original CREDENCE trial was registered at ClinicalTrials.gov with study number NCT02065791.
Kidney and Cardiovascular Effects of Canagliflozin According to Age and Sex: A Post Hoc Analysis of the CREDENCE Randomized Clinical Trial
Yi, Tae Won;Smyth, Brendan;Di Tanna, Gian Luca;Arnott, Clare;Cardoza, Kathryn;Kang, Amy;Pollock, Carol;Agarwal, Rajiv;Bakris, George;Charytan, David M.;de Zeeuw, Dick;Heerspink, Hiddo J. L.;Neal, Bruce;Wheeler, David C.;Cannon, Christopher P.;Zhang, Hong;Zinman, Bernard;Perkovic, Vlado;Levin, Adeera;Mahaffey, Kenneth W.;Jardine, Meg;Perkovic, Vlado;Mahaffey, Kenneth W.;Agarwal, Rajiv;Bakris, George;Brenner, Barry M.;Cannon, Christopher P.;Charytan, David M.;de Zeeuw, Dick;Greene, Tom;Jardine, Meg J.;Heerspink, Hiddo J. L.;Levin, Adeera;Meininger, Gary;Neal, Bruce;Pollock, Carol;Wheeler, David C.;Zhang, Hong;Zinman, Bernard;Jardine, Meg;Heerspink, Hiddo J. L.;Charytan, David M.;Li, Nicole;Kolesnyk, Inna;Aizenberg, Diego;Pecoits-Filho, Roberto;Levin, Adeera;Cherney, David;Obrador, Gregorio;Chertow, Glenn;Chang, Tara;Hawley, Carmel;Ji, Linong;Zhang, Hong;Wada, Takashi;Jha, Vivekanand;Lim, Soo Kun;Lim-Abrahan, Mary Anne;Santos, Florence;Chae, Dong-Wan;Hwang, Shang-Jyh;Vazelov, Evgueniy;Rychlík, Ivan;Hadjadj, Samy;Krane, Vera;Rosivall, László;De Nicola, Luca;Dreval, Alexander;Nowicki, Michał;Schiller, Adalbert;Distiller, Larry;Górriz, Jose L.;Kolesnyk, Mykola;David, null;Wheeler, C.;Guerrero, Rodolfo Andres Ahuad;Aizenberg, Diego;Albisu, Juan Pablo;Alvarisqueta, Andres;Bartolacci, Ines;Berli, Mario Alberto;Bordonava, Anselmo;Calella, Pedro;Cantero, Maria Cecilia;Cartasegna, Luis Rodolfo;Cercos, Esteban;Coloma, Gabriela Cecilia;Colombo, Hugo;Commendatore, Victor;Cuadrado, Jesus;Cuneo, Carlos Alberto;Cusumano, Ana Maria;Douthat, Walter Guillermo;Dran, Ricardo Dario;Farias, Eduardo;Fernandez, Maria Florencia;Finkelstein, Hernan;Fragale, Guillermo;Fretes, Jose Osvaldo;Garcia, Nestor Horacio;Gastaldi, Anibal;Gelersztein, Elizabeth;Glenny, Jorge Archibaldo;Gonzalez, Joaquin Pablo;Colaso, Patricia del Carmen Gonzalez;Goycoa, Claudia;Greloni, Gustavo Cristian;Guinsburg, Adrian;Hermida, Sonia;Juncos, Luis Isaias;Klyver, Maria Isabel;Kraft, Florencia;Krynski, Fernando;Lanchiotti, Paulina Virginia;Leon de la Fuente, Ricardo Alfonso;Marchetta, Nora;Mele, Pablo;Nicolai, Silvia;Novoa, Pablo Antonio;Orio, Silvia Ines;Otreras, Fabian;Oviedo, Alejandra;Raffaele, Pablo;Resk, Jorge Hector;Rista, Lucas;Papini, Nelson Rodriguez;Sala, Jorgelina;Santos, Juan Carlos;Schiavi, Lilia Beatriz;Sessa, Horacio;Casabella, Tomas Smith;Ulla, Maria Rosa;Valdez, Maria;Vallejos, Augusto;Villarino, Adriana;Visco, Virginia Esther;Wassermann, Alfredo;Zaidman, Cesar Javier;Cheung, Ngai Wah;Droste, Carolyn;Fraser, Ian;Johnson, David;Mah, Peak Mann;Nicholls, Kathy;Packham, David;Proietto, Joseph;Roberts, Anthony;Roger, Simon;Tsang, Venessa;Raduan, Roberto Abrão;Costa, Fernando Augusto Alves da;Amodeo, Celso;Turatti, Luiz Alberto Andreotti;Bregman, Rachel;Sanches, Fernanda Cristina Camelo;Canani, Luis Henrique;Chacra, Antônio Roberto;Borges, João Lindolfo Cunha;Vêncio, Sérgio Alberto Cunha;Franco, Roberto Jorge da Silva;d’Avila, Domingos;Portes, Evandro de Souza;de Souza, Pedro;Deboni, Luciane Mônica;Fraige Filho, Fadlo;Neto, Bruno Geloneze;Gomes, Marcus;Kohara, Suely Keiko;Keitel, Elizete;Saraiva, Jose Francisco Kerr;Lisboa, Hugo Roberto Kurtz;Contieri, Fabiana Loss de Carvalho;Milagres, Rosângela;Junior, Renan Montenegro;de Brito, Claudia Moreira;Hissa, Miguel Nasser;Sabbag, Ângela Regina Nazario;Noronha, Irene;Panarotto, Daniel;Filho, Roberto Pecoits;Pereira, Márcio Antônio;Saporito, Wladmir;Scotton, Antonio Scafuto;Schuch, Tiago;de Almeida, Roberto Simões;Ramos, Cássio Slompo;Felício, João Soares;Thomé, Fernando;Hachmann, Jean Carlo Tibes;Yamada, Sérgio;Hayashida, Cesar Yoiti;Petry, Tarissa Beatrice Zanata;Zanella, Maria Teresa;Andreeva, Viktoria;Angelova, Angelina;Dimitrov, Stefan;Genadieva, Veselka;Genova-Hristova, Gabriela;Hristozov, Kiril;Kamenov, Zdravko;Koundurdjiev, Atanas;Lozanov, Lachezar;Margaritov, Viktor;Nonchev, Boyan;Rangelov, Rangel;Shinkov, Alexander;Temelkova, Margarita;Velichkova, Ekaterina;Yakov, Andrian;Aggarwal, Naresh;Aronson, Ronnie;Bajaj, Harpreet;Cherney, David;Chouinard, Guy;Conway, James;Cournoyer, Serge;DaRoza, Gerald;De Serres, Sacha;Dubé, François;Goldenberg, Ronald;Gupta, Anil;Gupta, Milan;Henein, Sam;Khandwala, Hasnain;Leiter, Lawrence;Levin, Adeera;Madore, François;McMahon, Alan;Muirhead, Norman;Pichette, Vincent;Rabasa-Lhoret, Remi;Steele, Andrew;Tangri, Navdeep;Torshizi, Ali;Woo, Vincent;Zalunardo, Nadia;Montenegro, María Alicia Fernández;Gonzalo Godoy Jorquera, Juan;Fariña, Marcelo Medina;Gajardo, Victor Saavedra;Vejar, Margarita;Chen, Nan;Chen, Qinkai;Gan, Shenglian;Kong, Yaozhong;Li, Detian;Li, Wenge;Li, Xuemei;Lin, Hongli;Liu, Jian;Lu, Weiping;Mao, Hong;Ren, 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Pierre-Jean;Thervet, Eric;Zaoui, Philippe;Burst, Volker;Faghih, Markus;Faulmann, Grit;Haller, Hermann;Jerwan-Keim, Reinhold;Maxeiner, Stephan;Paschen, Björn;Plassmann, Georg;Rose, Ludger;Gonzalez Orellana, Ronaldo Arturo;Haase, Franklin Paul;Moreira Diaz, Juan Pablo;Ramirez Roca, Luis Alberto;Sánchez Arenales, Jose Antonio;Sanchez Polo, José Vicente;Juarez, Erick Turcios;Csecsei, Gyongyi;Csiky, Botond;Danos, Peter;Deak, Laszlo;Dudas, Mihaly;Harcsa, Eleonora;Keltai, Katalin;Keresztesi, Sandor;Kiss, Krisztian;Konyves, Laszlo;Major, Lajos;Mileder, Margit;Molnar, Marta;Mucsi, Janos;Oroszlan, Tamas;Ory, Ivan;Paragh, Gyorgy;Peterfai, Eva;Petro, Gizella;Revesz, Katalin;Takacs, Robert;Vangel, Sandor;Vasas, Szilard;Zsom, Marianna;Abraham, Oomman;Bhushan, Raju Sree;Deepak, Dewan;Edwin, Fernando M.;Gopalakrishnan, Natarajan;Gracious, Noble;Hansraj, Alva;Jain, Dinesh;Keshavamurthy, C. B.;Khullar, Dinesh;Manisha, Sahay;Peringat, Jayameena;Prasad, Narayan;Satyanarayana, Rao K.;Sreedhar, Reddy;Sreelatha, Melemadathil;Sudhakar, Bhimavarapu;Chandra Vyasam, Ramesh;Bonadonna, Riccardo;Castellino, Pietro;Ceriello, Antonio;Chiovato, Luca;De Cosmo, Salvatore;De Nicola, Luca;Derosa, Giuseppe;Di Carlo, Alberto;Di Cianni, Graziano;Frascà, Giovanni;Fuiano, Giorgio;Gambaro, Giovanni;Garibotto, Giacomo;Giorda, Carlo;Malberti, Fabio;Mandreoli, Marcora;Mannucci, Edoardo;Orsi, Emanuela;Piatti, Piermarco;Santoro, Domenico;Sasso, Ferdinando Carlo;Serviddio, Gaetano;Stella, Andrea;Trevisan, Roberto;Veronelli, Anna Maria;Zanoli, Luca;Akiyama, Hitoshi;Aoki, Hiromi;Asano, Akimichi;Iitsuka, Tadashi;Kajiyama, Shizuo;Kashine, Susumu;Kawada, Toshio;Kodera, Takamoto;Kono, Hiroshi;Koyama, Kazunori;Kumeda, Yasuro;Miyauchi, Shozo;Mizuyama, Kazuyuki;Niiya, Tetsuji;Oishi, Hiroko;Ota, Satoshi;Sakakibara, Terue;Takai, Masahiko;Tomonaga, Osamu;Tsujimoto, Mitsuru;Wada, Takashi;Wakasugi, Masakiyo;Wakida, Yasushi;Watanabe, Takayuki;Yamada, Masayo;Yanagida, Kazuhiro;Yanase, Toshihiko;Yumita, Wataru;Gaupsiene, Egle;Kozloviene, Dalia;Navickas, Antanas;Urbanaviciene, Egle;Abdul Ghani, Rohana;Kadir, Khalid Abdul;Ali, Norsiah;Che Yusof, Mohd Daud;Gan, Chye Lee;Ismail, Mastura;Kong, Wei Yen;Lam, Swee Win;Lee, Li Yuan;Lim, Soo Kun;Loh, Chek Loong;Manocha, Anita Bhajan;Ng, Kee Sing;Ahmad, Nik Nur Fatnoon Nik;Ratnasingam, Vanassa;Shudim, Saiful Shahrizal Bin;Vengadasalam, Paranthaman;Abraira Munoz, Luis David;Salazar, Melchor Alpizar;Cruz, Juan Baas;Soto, Mario Burgos;Ramos, Jose Chevaile;Wong, Alfredo Chew;Correa Rotter, Jose Ricardo;Escalante, Tonatiu Diaz;Enriquez Sosa, Favio Edmundo;Lozano, Fernando Flores;Flota Cervera, Luis Fernando;Baron, Paul Frenk;Ballesteros, Cecilia Garcia;Gomez Rangel, Jose David;Herrera Jimenez, Luis Enrique;Irizar Santana, Sergio Saul;Flores, Fernando Jimenez;Molina, Hugo Laviada;Luna Ceballos, Rosa Isela;del Campo Blanco, Belia Martin;Franco, Guadalupe Morales;Moreno Loza, Oscar Tarsicio;Rocha, Cynthia Mustieles;Vera, Gregorio Obrador;Castellanos, Ricardo Orozco;Calcaneo, Juan Peralta;Reyes Rosano, Miguel Angel;Pattzi, Hiromi Rodriguez;Guzman, Juan Rosas;Rucker Joerg, Isabel Erika;Saavedra Sanchez, Sandra Berenice;Sanchez Mijangos, Jose Hector;Sanson, Pablo Serrano;Tamayo y Orozco, Juan Alfredo;Chavez, Eloisa Tellez;Cepeda, Alejandro Valdes;Carrillo, Luis Venegas;Mesa, Juan Villagordoa;Escobedo, Rolando Zamarripa;Baker, John;Noonan, Paul;Scott, Russell;Walker, Robert;Watson, Edward;Williams, Michael;Young, Simon;Abejuela, Zaynab;Agra, Jeimeen;Aquitania, Grace;Caringal, Clodoaido;Comia, Rhea Severina;Santos, Lalaine Delos;Gomez, Olivert;Jimeno, Cecilia;Santos, Florence;Tan, Gerry;Tolentino, Marsha;Yao, Christy;Yap, Yvette Ethel;Lallaine Ygpuara, Ma. Dovie;Bijata-Bronisz, Renata;Hotlos, Lucyna;Januszewicz, Andrzej;Kaczmarek, Barbara;Kaminska, Anna;Lazuka, Lech;Madej, Andrzej;Mazur, Stanislaw;Mlodawska-Choluj, Dorota;Nowicki, Michal;Orlowska-Kowalik, Grazyna;Popenda, Grazyna;Rewerska, Barbara;Sowinski, Dariusz;Angelescu, Liliana Monica;Anghel, Veronica;Avram, Rodica-Ioana;Busegeanu, Mihaela-Magdalena;Cif, Adriana;Cosma, Dana;Crisan, Carmen;Demian, Luiza Despina;Ferariu, Ioana Emilia;Halmagyi, Ildiko;Hancu, Nicolae;Munteanu, Mircea;Negru, Doru;Onaca, Adriana Gabriela;Petrica, Ligia;Popa, Amorin Remus;Ranetti, Aurelian-Emil;Serafinceanu, Cristian;Toarba, Cristina;Agafyina, Alina;Barbarash, Olga;Barysheva, Olga;Chizhov, Daniil;Dobronravov, Vladimir;Dreval, Alexander;Glinkina, Irina;Grineva, Elena;Khirmanov, Vladimir;Kolmakova, Elena;Koroleva, Tatiana;Kvitkova, Liudmila;Marasaev, Viacheslav;Mkrtumyan, Ashot;Morugova, Tatiana;Nagibovich, Galina;Nagibovich, Oleg;Nedogoda, Sergei;Osipova, Irina;Raskina, Tatiana;Samoylova, Yulia;Sazonova, Olga;Shamkhalova, Minara;Shutemova, Elena;Shwartz, Yuriy;Uriasyev, Oleg;Vorobyev, Sergey;Zateyshchikova, Anna;Zateyshshikov, Dmitry;Zykova, Tatyana;Antic, Slobodan;Djordjevic, Miodrag;Kendereski, Aleksandra;Lalic, Katarina;Lalic, Nebojsa;Popovic-Radinovic, Vesna;Babikova, Jana;Benusova, Olga;Buganova, Ingrid;Culak, Jan;Dzupina, Andrej;Dzuponova, Jana;Fulop, Peter;Ilavska, Adriana;Martinka, Emil;Ochodnicka, Zuzana;Pella, Daniel;Smatanova, Iveta;Ahmed, Fayzal;Badat, Aysha;Breedt, Johannes;Distiller, Lawrence;Govender, Vimladhevi;Govender, Ravendran;Joshi, Mukesh;Jurgens, Jaco;Latiff, Gulam;Lombard, Landman;Mookadam, Mohamed;Ngcakani, Nomangesi;Nortje, Hendrik;Oosthuizen, Helena;Pillay-Ramaya, Larisha;Prozesky, Hans;Reddy, Jeevren;Rheeder, Paul;Seeber, Mary;Chae, Dong-Wan;Cho, Young Min;Jeong, In-Kyung;Kim, Sin Gon;Kim, Yeong Hoon;Kwon, Hyuk-Sang;Kwon, Min Jeong;Lee, Byung-Wan;Lee, JungEun;Lee, Moon-Kyu;Nam, Moon-Suk;Oh, Kook-Hwan;Park, Cheol- Young;Park, Sun-Hee;Yoon, Kun Ho;Garcia, Pere Alvarez;Mercadal, Luis Asmarats;Barrios, Clara;Castro, Fernando Cereto;Guldris, Secundino Cigarran;Lopez, Marta Dominguez;Egido de los Rios, Jesus;Fresnedo, Gema Fernandez;Serrano, Antonio Galan;Garcia, Isabel;Gonzalez Martinez, Francisco Javier;Jodar Gimeno, Jose Esteban;Mendoza, Manuel Lopez;Marin, Tamara Malek;Portillo, Cristobal Morales;Munar Vila, Maria Antonia;Torres, Manuel Muñoz;Iglesias, Javier Nieto;Perez, Jonay Pantoja;Vera, Merce Perez;Portoles Perez, Jose M.;Quesada Simón, María Angustias;Canonge, Rafael Simo;Gonzalez, Alfonso Soto;Riera, Manel Terns;Tinahones Madueno, Francisco Jose;Plaza, Mercedes Velo;Chang, Chwen-Tzuei;Chuang, Lee-Ming;Hsia, Te-Lin;Hsieh, Chang-Hsun;Hwang, Shang-Jyh;Lin, Chih-Ching;Lu, Yung- Chuan;Sheu, Wayne H-H;Barna, Olga;Bilyk, Svitlana D.;Botsyurko, Volodymyr;Dudar, Iryna;Fushtey, Ivan;Godlevska, Olga;Golovchenko, Oleksandr;Gyrina, Olga;Kazmirchuk, Anatoliy;Kolesnyk, Mykola;Komisarenko, Iuliia;Korzh, Oleksii;Kravchun, Nonna;Legun, Oleg;Mankovskyy, Borys;Martynyuk, Liliya;Mostovoy, Yuriy;Pashkovska, Nataliia;Pererva, Larysa;Pertseva, Tetyana;Samoylov, Oleksandr;Smirnov, Ivan;Svyshchenko, Yevgeniya;Tomashkevych, Halyna;Topchii, Ivan;Tryshchuk, Nadiya;Tseluyko, Vira;Vizir, Vadym;Vlasenko, Maryna;Zlova, Tetiana;Zub, Liliia;Abusnana, Salah;Railey, Mohamed;Abouglila, Kamal;Ainsworth, Paul;Ali, Zishan;Arutchelvam, Vijayaraman;Barnard, Maria;Bellary, Srikanth;Davies, Emyr;Davies, Mark;Davies, Simon;Dawson, Alison;El Kossi, Mohsen;English, Patrick;Fraser, Donald;Gnudi, Luigi;Gunstone, Anthony;Hall, Timothy;Hanif, Wasim;Jackson, Alan;Johnson, Andrew;Joseph, Franklin;Krishnan, Singhan;Kumwenda, Mick;MacDougall, Iain;Nixon, Paul;O'Hare, Joseph;Philip, Sam;Ramtoola, Shenaz;Saxena, Manish;Sennik, Davesh;Simon, Godwin;Singh, Baldev;Stephens, Jeffrey;Strzelecka, Anna;Symonds, Rehan;Turner, Wayne;Wahba, Mona;Wakeling, John;Wheeler, David;Winocour, Peter;Abdallah, Joseph;Abdullah, Raied;Abramowitz, Matthew;Acosta, Idalia;Aiello, Joseph;Akright, 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2023-01-01
Abstract
Rationale & Objective: It is unclear whether the effect of canagliflozin on adverse kidney and cardiovascular events in those with diabetic kid-ney disease varies by age and sex. We assessed the effects of canagliflozin among age group categories and between sexes in the Canagli-flozin and Renal Endpoints in Diabetes with Established Nephropathy Clinical Evaluation (CREDENCE) study.Study Design: Secondary analysis of a random-ized controlled trial. Setting & Participants: Participants in the CREDENCE trial. Intervention: Participants were randomly assigned to receive canagliflozin 100 mg/d or placebo.Outcomes: Primary composite outcome of kid-ney failure, doubling of serum creatinine con-centration, or death due to kidney or cardiovascular disease. Prespecified secondary and safety outcomes were also analyzed. Out-comes were evaluated by age at baseline (<60, 60-69, and >_70 years) and sex in the intention-to-treat population using Cox regression models.Results: The mean age of the cohort was 63.0 & PLUSMN; 9.2 years, and 34% were female. Older age and female sex were independently associ-ated with a lower risk of the composite of adverse kidney outcomes. There was no evidence that the effect of canagliflozin on the primary outcome (acomposite of kidney failure, a doubling of serum creatinine concentration, or death from kidney or cardiovascular causes) differed between age groups (HRs, 0.67 [95% CI, 0.52-0.87], 0.63 [0.4 8-0.82], and 0.89 [0.61-1.29] for ages <60, 60-69, and >_70 years, respectively; P = 0.3 for interaction) or sexes (HRs, 0.71 [95% CI, 0.5 4-0.95] and 0.69 [0.56-0.8 4] in women and men, respectively; P = 0.8 for interaction). No differences in safety outcomes by age group or sex were observed.Limitations: This was a post hoc analysis with multiple comparisons.Conclusions: Canagliflozin consistently reduced the relative risk of kidney events in people with diabetic kidney disease in both sexes and across age subgroups. As a result of greater background risk, the absolute reduction in adverse kidney outcomes was greater in younger participants.Funding: This post hoc analysis of the CREDENCE trial was not funded. The CREDENCE study was sponsored by Janssen Research and Development and was conducted collaboratively by the sponsor, an academic-led steering committee, and an academic research organization, George Clinical.Trial Registration: The original CREDENCE trial was registered at ClinicalTrials.gov with study number NCT02065791.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11570/3286333
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simulazione ASN
Il report seguente simula gli indicatori relativi alla propria produzione scientifica in relazione alle soglie ASN 2023-2025 del proprio SC/SSD. Si ricorda che il superamento dei valori soglia (almeno 2 su 3) è requisito necessario ma non sufficiente al conseguimento dell'abilitazione. La simulazione si basa sui dati IRIS e sugli indicatori bibliometrici alla data indicata e non tiene conto di eventuali periodi di congedo obbligatorio, che in sede di domanda ASN danno diritto a incrementi percentuali dei valori. La simulazione può differire dall'esito di un’eventuale domanda ASN sia per errori di catalogazione e/o dati mancanti in IRIS, sia per la variabilità dei dati bibliometrici nel tempo. Si consideri che Anvur calcola i valori degli indicatori all'ultima data utile per la presentazione delle domande.
La presente simulazione è stata realizzata sulla base delle specifiche raccolte sul tavolo ER del Focus Group IRIS coordinato dall’Università di Modena e Reggio Emilia e delle regole riportate nel DM 589/2018 e allegata Tabella A. Cineca, l’Università di Modena e Reggio Emilia e il Focus Group IRIS non si assumono alcuna responsabilità in merito all’uso che il diretto interessato o terzi faranno della simulazione. Si specifica inoltre che la simulazione contiene calcoli effettuati con dati e algoritmi di pubblico dominio e deve quindi essere considerata come un mero ausilio al calcolo svolgibile manualmente o con strumenti equivalenti.