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EnglishUsing fluorescence histochemistry, we have examined the origin of noradrenaline (NA)-, 5-hydroxytryptamine (5-HT)- and neuropeptide Y (NPY)-containing perivascular nerve fibres supplying the major cerebral arteries of the gerbil, and the effect of superior cervical ganglionectomy on their cerebrovascular density and distribution. Bilateral ganglionectomy resulted in a complete loss of these perivascular nerve types in the anterior circulation, while a few fibres still persisted in the posterior circulatory bed. In addition, we demonstrate the presence of both 5-HT- and NPY-positive cell bodies in the superior cervical ganglion (SCG) of adult gerbils, suggesting that the main origin of cerebrovascular 5-HT- and NPY- (as well as NA-) containing nerve fibres is in the SCG.
| Titolo: | Histochemical and immunohistochemical study of noradrenergic, serotonergic and peptidergic innervation of the cerebral circulation. |
| Autori: | |
| Data di pubblicazione: | 1987 |
| Rivista: | |
| Abstract: | Using fluorescence histochemistry, we have examined the origin of noradrenaline (NA)-, 5-hydroxytryptamine (5-HT)- and neuropeptide Y (NPY)-containing perivascular nerve fibres supplying the major cerebral arteries of the gerbil, and the effect of superior cervical ganglionectomy on their cerebrovascular density and distribution. Bilateral ganglionectomy resulted in a complete loss of these perivascular nerve types in the anterior circulation, while a few fibres still persisted in the posterior circulatory bed. In addition, we demonstrate the presence of both 5-HT- and NPY-positive cell bodies in the superior cervical ganglion (SCG) of adult gerbils, suggesting that the main origin of cerebrovascular 5-HT- and NPY- (as well as NA-) containing nerve fibres is in the SCG. |
| Handle: | http://hdl.handle.net/11570/11733 |
| Appare nelle tipologie: | 14.a.1 Articolo su rivista |
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