A new ring opening reaction of isoxazolidine nucleus is reported, which is based on the treatment of 3-carboxyalkyl-substituted derivatives with NaH. The process results in a new and general synthetic pathway towards the formation of 3-methylamino-2(5H)furanones.

Ring-opening of the isoxazolidine system: a new synthesis of 2-amino-5H-furanones

ROMEO, Giovanni;ROMEO, Roberto;
1995-01-01

Abstract

A new ring opening reaction of isoxazolidine nucleus is reported, which is based on the treatment of 3-carboxyalkyl-substituted derivatives with NaH. The process results in a new and general synthetic pathway towards the formation of 3-methylamino-2(5H)furanones.
1995
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11570/1552
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