The diastereo- and enantioselective synthesis of alfa and beta 3-hydroxymethyl-N,O-nucleosides is described, based on the 1,3-dipolar cycloaddition of a N-glycosyl nitrone. Two approaches have been evaluated: the one-step procedure, which uses vinyl nucleobases, showed a better stereoselectivity towards beta-nucleosides
Diastereo- and enantioselective synthesis of N,O-nucleosides
IANNAZZO, Daniela;PIPERNO, Anna;ROMEO, Roberto;ROMEO, Giovanni
2003-01-01
Abstract
The diastereo- and enantioselective synthesis of alfa and beta 3-hydroxymethyl-N,O-nucleosides is described, based on the 1,3-dipolar cycloaddition of a N-glycosyl nitrone. Two approaches have been evaluated: the one-step procedure, which uses vinyl nucleobases, showed a better stereoselectivity towards beta-nucleosidesFile in questo prodotto:
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