A flexible synthetic procedure to access a new and biologically interesting class of N,O-psiconucleosides by 1,3-dipolar cycloaddition of C-ethoxycarbonyl-N-methyl nitrone with ethyl 2-(acetyloxy)acrylate, followed by Vorbruggen nucleosidation and sodium borohydride reduction, is described.
Diastereoselective synthesis of N,O-psiconucleosides via 1,3- dipolar cycloadditions
IANNAZZO, Daniela;PIPERNO, Anna;ROMEO, Roberto;ROMEO, Giovanni
2001-01-01
Abstract
A flexible synthetic procedure to access a new and biologically interesting class of N,O-psiconucleosides by 1,3-dipolar cycloaddition of C-ethoxycarbonyl-N-methyl nitrone with ethyl 2-(acetyloxy)acrylate, followed by Vorbruggen nucleosidation and sodium borohydride reduction, is described.File in questo prodotto:
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