Two strategies for the enantioselective synthesis of some isoxazolidinyl nucleosides, as potential antiviral drugs, are reported. In particular, a one-step approach based on 1,3-dipolar cycloaddition with vinyl nucleobases and a two-step methodology based on the Vorbrüggen nucleosidation have been exploited in the preparation of 4'-aza-2',3'-dideoxynucleoside analogues containing uracil, 5-fluorouracil, thymine and cytosine.

Enantioselective synthesis of isoxazolidinyl nucleosides containing uracil, 5-fluorouracil, thymine and cytosine as new potential anti-HIV drugs

IANNAZZO, Daniela;PIPERNO, Anna;ROMEO, Giovanni;ROMEO, Roberto;
2002-01-01

Abstract

Two strategies for the enantioselective synthesis of some isoxazolidinyl nucleosides, as potential antiviral drugs, are reported. In particular, a one-step approach based on 1,3-dipolar cycloaddition with vinyl nucleobases and a two-step methodology based on the Vorbrüggen nucleosidation have been exploited in the preparation of 4'-aza-2',3'-dideoxynucleoside analogues containing uracil, 5-fluorouracil, thymine and cytosine.
2002
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11570/1599243
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