Two strategies for the enantioselective synthesis of some isoxazolidinyl nucleosides, as potential antiviral drugs, are reported. In particular, a one-step approach based on 1,3-dipolar cycloaddition with vinyl nucleobases and a two-step methodology based on the Vorbrüggen nucleosidation have been exploited in the preparation of 4'-aza-2',3'-dideoxynucleoside analogues containing uracil, 5-fluorouracil, thymine and cytosine.
Enantioselective synthesis of isoxazolidinyl nucleosides containing uracil, 5-fluorouracil, thymine and cytosine as new potential anti-HIV drugs
IANNAZZO, Daniela;PIPERNO, Anna;ROMEO, Giovanni;ROMEO, Roberto;
2002-01-01
Abstract
Two strategies for the enantioselective synthesis of some isoxazolidinyl nucleosides, as potential antiviral drugs, are reported. In particular, a one-step approach based on 1,3-dipolar cycloaddition with vinyl nucleobases and a two-step methodology based on the Vorbrüggen nucleosidation have been exploited in the preparation of 4'-aza-2',3'-dideoxynucleoside analogues containing uracil, 5-fluorouracil, thymine and cytosine.File in questo prodotto:
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