We describe two patients affected by recurring epileptic seizures and mental retardation, with high levels of plasmatic and urinary proline. Recent findings suggest that proline, at high concentrations (> 100 μM), regulates the basal function of some glutamate synapses by maintaining them in a partially potentiated state. Thus, the recurrence of seizures in the developmental age could be due to the hyperstimulation of glutamate by proline.
Epilessia parziale farmacoresistente e iperprolinemia: descrizione di due casi clinici
DI ROSA, GABRIELLA;TORTORELLA, Gaetano
2003-01-01
Abstract
We describe two patients affected by recurring epileptic seizures and mental retardation, with high levels of plasmatic and urinary proline. Recent findings suggest that proline, at high concentrations (> 100 μM), regulates the basal function of some glutamate synapses by maintaining them in a partially potentiated state. Thus, the recurrence of seizures in the developmental age could be due to the hyperstimulation of glutamate by proline.File in questo prodotto:
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