Hyperlipidemia is a well-known risk factor for atherosclerosis, and its control is crucial in the prevention of cardiovascular diseases, especially when other risk factors, such as diabetes mellitus, hypertension, obesity, family history, or smoking, are present. In Western countries, the 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA) inhibitors, or statins, are used to decrease total cholesterol levels in hyperlipidemic subjects.1 They appear safe and well tolerated, but they can have muscle side effects, ranging from myalgias and cramps to muscle weakness and even myoglobinuria.2,3 The real incidence and the pathogenetic mechanisms of statin-induced myopathy, as well as its duration after discontinuation of the drug, are a matter of discussion.4 In the presence of adverse effects, alternative measures to control blood lipid levels include the use of so-called natural products.
Chinese red rice depletes muscle coenzyme Q10 and mantains muscle damage after discontinuation of statin treatment.
RODOLICO, Carmelo;MUSUMECI, Olimpia;
2006-01-01
Abstract
Hyperlipidemia is a well-known risk factor for atherosclerosis, and its control is crucial in the prevention of cardiovascular diseases, especially when other risk factors, such as diabetes mellitus, hypertension, obesity, family history, or smoking, are present. In Western countries, the 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA) inhibitors, or statins, are used to decrease total cholesterol levels in hyperlipidemic subjects.1 They appear safe and well tolerated, but they can have muscle side effects, ranging from myalgias and cramps to muscle weakness and even myoglobinuria.2,3 The real incidence and the pathogenetic mechanisms of statin-induced myopathy, as well as its duration after discontinuation of the drug, are a matter of discussion.4 In the presence of adverse effects, alternative measures to control blood lipid levels include the use of so-called natural products.Pubblicazioni consigliate
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