Alpha-synuclein belongs to a family of vertebrate proteins, encoded by three different genes: α, β, and γ. The protein has become of interest to the neuroscience community in the last few years after the discovery that a mutation in the α-synuclein gene is associated with familial autosomal-dominant early-onset forms of Parkinson Disease. However, it is not yet clear how the protein is involved in the disease. Several studies have suggested that α-synuclein plays a role in neurotransmitter release and synaptic plasticity. This hypothesis might help elucidate how α-synuclein malfunctioning contributes to the development of a series of disorders known as synucleinopathies.
Alpha-synuclein: between synaptic function and dysfunction
DI ROSA, GABRIELLA;SANT'ANGELO, ANTONINO;
2003-01-01
Abstract
Alpha-synuclein belongs to a family of vertebrate proteins, encoded by three different genes: α, β, and γ. The protein has become of interest to the neuroscience community in the last few years after the discovery that a mutation in the α-synuclein gene is associated with familial autosomal-dominant early-onset forms of Parkinson Disease. However, it is not yet clear how the protein is involved in the disease. Several studies have suggested that α-synuclein plays a role in neurotransmitter release and synaptic plasticity. This hypothesis might help elucidate how α-synuclein malfunctioning contributes to the development of a series of disorders known as synucleinopathies.Pubblicazioni consigliate
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