RuO2/NaIO4 oxidation of 3-unsubstituted isoxazolidines, under ethyl acetate/water biphasic conditions, affords 3-isoxazolidones in good yields. The methodology can be used on both racemic and optically active isoxazolidines.
Fist example of direct RuO4-Catalyzed oxidation of isoxazolidines to 3-isoxazolidones
PIPERNO, Anna;IANNAZZO, Daniela;GIOFRE', Salvatore Vincenzo;ROMEO, Giovanni;ROMEO, Roberto
2007-01-01
Abstract
RuO2/NaIO4 oxidation of 3-unsubstituted isoxazolidines, under ethyl acetate/water biphasic conditions, affords 3-isoxazolidones in good yields. The methodology can be used on both racemic and optically active isoxazolidines.File in questo prodotto:
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