We investigated the effects of indolepyruvic acid administration (25, 50 and 100 mg/kg by oral gavage) on food consumption and body weight in male obese Zucker rats (fa/fa) and in their lean age matched controls (FA/?; FA/FA), both aged 16 weeks. Tryptophan, serotonin, and 5-hydroxyindoleacetic acid (5-HIAA) were measured in discrete brain areas. Acute or repeated administration of indolepyruvic acid reduced food intake and body weight in both obese and lean rats. However lean rats showed tolerance to indolepyruvic effects after 5 days of treatment. Furthermore, indolepyruvic acid enhanced serotonin metabolism in the cortex diencephalon and medulla-pons. Finally indolepyruvic acid anorexia was abated by pretreatment with metergoline. These data suggest that indolepyruvic acid may represent a new anorectic drug
INDOLEPYRUVIC ACID, A TRYPTOPHAN KETO ANALOG, REDUCES FOOD- INTAKE IN OBESE ZUCKER RATS
SQUADRITO, Francesco;CALAPAI, Gioacchino;CAMPO, Giuseppe Maurizio;ARCORACI, Vincenzo;CUCINOTTA, Domenico Maria;SAITTA, Antonino;CAPUTI, Achille
1991-01-01
Abstract
We investigated the effects of indolepyruvic acid administration (25, 50 and 100 mg/kg by oral gavage) on food consumption and body weight in male obese Zucker rats (fa/fa) and in their lean age matched controls (FA/?; FA/FA), both aged 16 weeks. Tryptophan, serotonin, and 5-hydroxyindoleacetic acid (5-HIAA) were measured in discrete brain areas. Acute or repeated administration of indolepyruvic acid reduced food intake and body weight in both obese and lean rats. However lean rats showed tolerance to indolepyruvic effects after 5 days of treatment. Furthermore, indolepyruvic acid enhanced serotonin metabolism in the cortex diencephalon and medulla-pons. Finally indolepyruvic acid anorexia was abated by pretreatment with metergoline. These data suggest that indolepyruvic acid may represent a new anorectic drugPubblicazioni consigliate
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
