A new method for the synthesis of diversely functionalized oxazoles has been developed. The transformations consists of an acylation of enolizable cyclic 1,3-dicarbonyls by 5(4H)-oxazolones followed by rapid cyclization promoted by trifluoroacetic anhydride. Cyclization precursors have been prepared by a chemo- and regioselective method using DBU as catalyst under microwave irradiation.
A New Construction of Diversely Functionalized Oxazoles from Enolizable Cyclic 1,3-Dicarbonyls and 5(4H)-Oxazolones
CORDARO, Massimiliano;GRASSI, Giovanni;RISITANO, Francesco;SCALA, ANGELA
2009-01-01
Abstract
A new method for the synthesis of diversely functionalized oxazoles has been developed. The transformations consists of an acylation of enolizable cyclic 1,3-dicarbonyls by 5(4H)-oxazolones followed by rapid cyclization promoted by trifluoroacetic anhydride. Cyclization precursors have been prepared by a chemo- and regioselective method using DBU as catalyst under microwave irradiation.File in questo prodotto:
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