We herein report conventional and microwave-assisted methods for the synthesis of a series of compounds containing some bivalent ion chelating requirements useful to exert potential HIV-1 integrase (IN) enzyme inhibition activity. The biological screening highlighted that only derivative 5 proved to be a strand-transfer step inhibitor of the virus integration process at micromolar concentration.

Synthesis of new pyridazine derivatives as potential anti-HIV-1 agents

FERRO, Stefania;AGNELLO, STEFANO;DE LUCA, Laura;GITTO, Rosaria
2009-01-01

Abstract

We herein report conventional and microwave-assisted methods for the synthesis of a series of compounds containing some bivalent ion chelating requirements useful to exert potential HIV-1 integrase (IN) enzyme inhibition activity. The biological screening highlighted that only derivative 5 proved to be a strand-transfer step inhibitor of the virus integration process at micromolar concentration.
2009
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11570/1895358
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