CINECA IRIS Institutional Research Information System
IRIS è la soluzione IT che facilita la raccolta e la gestione dei dati relativi alle attività e ai prodotti della ricerca. Fornisce a ricercatori, amministratori e valutatori gli strumenti per monitorare i risultati della ricerca, aumentarne la visibilità e allocare in modo efficace le risorse disponibili.
EnglishStarting with 5-iodo N,O-nucleosides, prepared by 1,3-dipolar cycloaddition of nitrones with vinyliodouracil, or vinyl acetate followed by coupling with silylated iodouracil, a series of 5-alkynyl N,O-nucleosides were synthesized via a palladium-catalyzed (Sonogashira) coupling reaction. The cytotoxic activity of modified nucleosides against HEp-2 cell lines was determined in vitro. The 5-ethynyl N,O-nucleoside, the only compound in the series containing a terminal acetylene unit, was found to be the most active compound.
| Titolo: | Synthesis of 5-Alkynyl Isoxazolidinyl Nucleosides | |
| Autori: | ||
| Data di pubblicazione: | 2011 | |
| Rivista: | ||
| Abstract: | Starting with 5-iodo N,O-nucleosides, prepared by 1,3-dipolar cycloaddition of nitrones with vinyliodouracil, or vinyl acetate followed by coupling with silylated iodouracil, a series of 5-alkynyl N,O-nucleosides were synthesized via a palladium-catalyzed (Sonogashira) coupling reaction. The cytotoxic activity of modified nucleosides against HEp-2 cell lines was determined in vitro. The 5-ethynyl N,O-nucleoside, the only compound in the series containing a terminal acetylene unit, was found to be the most active compound. | |
| Handle: | http://hdl.handle.net/11570/1914991 | |
| Appare nelle tipologie: | 14.a.1 Articolo su rivista |
File in questo prodotto:
http://hdl.handle.net/11570/1914991
Copyright © 2021