The contractile response to endothelin has been examined in cerebral arteries from rats subjected to a prior subarachnoid haemorrhage (SAH) and compared with saline injected controls. Endothelin elicited strong concentration-dependent contraction of rat basilar artery segments. The response was slow in onset and long lasting. The endothelin-induced contraction was much stronger in the SAH compared to control animals. Our findings suggest a role of the peptide in the pathophysiology of cerebral vasospasm.

ENDOTHELIN - AN ENDOTHELIUM-DERIVED VASOACTIVE PEPTIDE AND ITS POSSIBLE ROLE IN THE PATHOGENESIS OF CEREBRAL VASOSPASM

ALAFACI, Concetta;SALPIETRO, Francesco;IACOPINO, Domenico;TOMASELLO, Francesco
1991-01-01

Abstract

The contractile response to endothelin has been examined in cerebral arteries from rats subjected to a prior subarachnoid haemorrhage (SAH) and compared with saline injected controls. Endothelin elicited strong concentration-dependent contraction of rat basilar artery segments. The response was slow in onset and long lasting. The endothelin-induced contraction was much stronger in the SAH compared to control animals. Our findings suggest a role of the peptide in the pathophysiology of cerebral vasospasm.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11570/2325264
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