Background The transcallosal approach provides a direct corridor to the lesions lying in the third ventricle with distinct advantages over alternative routes, such as the pos- sibility to use multiple corridors for tumor resection. Method Here we present a personal perspective of the sur- gery of tumors of the anterior portion of the third ventricle using this approach. Conclusions This approach requires the ability to move around many neurovascular, cortical, and white matter structures. Knowledge of regional anatomy and adherence to principles of microsurgery are basic requirements to obtain a favorable outcome.