Background: Peritoneal carcinomatosis of gastric origin is associated with poor survival. The use of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (HIPEC) did not improve significantly the survival of patients with this disease. A promising approach can be based on the use of HIPEC as prophylaxis of peritoneal dissemination. Patients and Methods: From our database, we have sampled 12 patients with advanced gastric cancer. In all cases, a D2 total gastrectomy was performed, associated in four cases with splenectomy. All patients were submitted to HIPEC. Results: Morbidity and mortality were 33.3% and 8.3%, respectively. The median survival was 24 months, with only one case (8.3%) of peritoneal recurrence. Conclusion: In light of our experience and supported by literature data, we can affirm that HIPEC has a potential role in the prevention of gastric carcinomatosis. Certainly further studies are needed on a large scale to validate this new but promising approach.
The role of prophylactic Hyperthermic Intraperitoneal Chemotherapy in the management of serosal involved gastric cancer.
SALADINO, EDOARDO;FLERES, FRANCESCO;MAZZEO, CARMELO;PRUITI CIARELLO, VINCENZO;SCOLLICA, MICHELA CARMELA;ROSSITTO, Maurizio;CUCINOTTA, Eugenio;MACRI', Antonio
2014-01-01
Abstract
Background: Peritoneal carcinomatosis of gastric origin is associated with poor survival. The use of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (HIPEC) did not improve significantly the survival of patients with this disease. A promising approach can be based on the use of HIPEC as prophylaxis of peritoneal dissemination. Patients and Methods: From our database, we have sampled 12 patients with advanced gastric cancer. In all cases, a D2 total gastrectomy was performed, associated in four cases with splenectomy. All patients were submitted to HIPEC. Results: Morbidity and mortality were 33.3% and 8.3%, respectively. The median survival was 24 months, with only one case (8.3%) of peritoneal recurrence. Conclusion: In light of our experience and supported by literature data, we can affirm that HIPEC has a potential role in the prevention of gastric carcinomatosis. Certainly further studies are needed on a large scale to validate this new but promising approach.Pubblicazioni consigliate
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