Arenediyne-isoxazolidine conjugates have been synthesized as a new scaffold for the development of bioactive mimics. Some of the synthesized compounds are endowed with antiproliferative activity against three human cancer cell lines. Their thermal reactivity suggests that the biological activity probably could not be linked to the Bergman cyclization.
Synthesis and biological activity of new arenediyne-linked isoxazolidines
ROMEO, Roberto;NAVARRA, Michele;GIOFRE', Salvatore Vincenzo;CARNOVALE, CATERINA;CIRMI, SANTA;
2014-01-01
Abstract
Arenediyne-isoxazolidine conjugates have been synthesized as a new scaffold for the development of bioactive mimics. Some of the synthesized compounds are endowed with antiproliferative activity against three human cancer cell lines. Their thermal reactivity suggests that the biological activity probably could not be linked to the Bergman cyclization.File in questo prodotto:
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