We report the determination of an effective protein-protein central potential for a lysozyme solution, obtained from the direct inversion of the total structure factor of the system, as extracted from small angle neutron scattering. The inversion scheme rests on a hypernetted-chain relationship between the effective potential and the structural functions, and is preliminarily tested for the case of a Lennard-Jones interaction. The characteristics of our potential are discussed in comparison with current models of effective interactions in complex fluids. The phase behavior predictions are also investigated.

Effective protein-protein interaction from structure factor data of a lysozyme solution

ABRAMO, Maria Concetta;CACCAMO, Carlo;COSTA, Dino;PELLICANE, Giuseppe;WANDERLINGH, Ulderico
2013-01-01

Abstract

We report the determination of an effective protein-protein central potential for a lysozyme solution, obtained from the direct inversion of the total structure factor of the system, as extracted from small angle neutron scattering. The inversion scheme rests on a hypernetted-chain relationship between the effective potential and the structural functions, and is preliminarily tested for the case of a Lennard-Jones interaction. The characteristics of our potential are discussed in comparison with current models of effective interactions in complex fluids. The phase behavior predictions are also investigated.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11570/2713168
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