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EnglishIn a short girl with celiac disease and Hashimoto's thyroiditis (HT), the suspect of an associated pituitary lesion was suggested by the finding of a thyroid function pattern that was not compatible with HTrelated hypothyroidism (low FT4 with normal TSH). This case report reinforces the view that the finding of a normal TSH in presence of a low FT4 should always alert pediatricians and raise the suspect of central hypothyroidism, even when a primary thyroid disease has been already identified. In this case TSH deficiency played a critical role in disclosing diagnosis of craniopharyngioma (CP). Therefore, the subsequent workup was directed towards investigating pituitary function and morphology. Endocrinological investigations evidenced a picture of TSH and other pituitary hormone deficiency, whereas magnetic resonance imaging revealed an intrasellar CP. Therefore, in this case TSH deficiency played a key-role in disclosing CP diagnosis. Conclusions: the finding of a normal TSH in presence of a low FT4 should always alert pediatricians and raise the suspect of CH, even when a primary thyroid disease has been already identified.
| Titolo: | Key-role of thyrotropin deficiency in disclosing craniopharyngioma diagnosis in a short girl with Hashimoto's thyroiditis. | |
| Autori: | AVERSA, Tommaso (Primo) WASNIEWSKA, Malgorzata Gabriela (Ultimo) | |
| Data di pubblicazione: | 2016 | |
| Rivista: | ||
| Abstract: | In a short girl with celiac disease and Hashimoto's thyroiditis (HT), the suspect of an associated pituitary lesion was suggested by the finding of a thyroid function pattern that was not compatible with HTrelated hypothyroidism (low FT4 with normal TSH). This case report reinforces the view that the finding of a normal TSH in presence of a low FT4 should always alert pediatricians and raise the suspect of central hypothyroidism, even when a primary thyroid disease has been already identified. In this case TSH deficiency played a critical role in disclosing diagnosis of craniopharyngioma (CP). Therefore, the subsequent workup was directed towards investigating pituitary function and morphology. Endocrinological investigations evidenced a picture of TSH and other pituitary hormone deficiency, whereas magnetic resonance imaging revealed an intrasellar CP. Therefore, in this case TSH deficiency played a key-role in disclosing CP diagnosis. Conclusions: the finding of a normal TSH in presence of a low FT4 should always alert pediatricians and raise the suspect of CH, even when a primary thyroid disease has been already identified. | |
| Handle: | http://hdl.handle.net/11570/2745570 | |
| Appare nelle tipologie: | 14.a.1 Articolo su rivista |
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| 16 - Aversa - craniopharyngioma - Minerva Pediatr 2016.pdf | Versione Editoriale (PDF) | Tutti i diritti riservati (All rights reserved) | Utenti riconosciuti Richiedi una copia |
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