Context: Autoimmune thyroid diseases (AITDs) can be associated with type 1 diabetes (DM1). The prevalence of serum antibodies against thyroid hormones (THAb) in subjects with autoimmune diseases other than DM1 is increasing. No data are available for DM1. Objective: The objectives were evaluate the rate of associated AITD; the rate of positiveness for serum THAb; the panel of THAb based on thyroid hormone interaction and on Ig class; and the association of AITD alone, THAb alone, or AITD plus THAb with diabetes-related complications. Design: This was an observational, prospective study with 6-year (2005-2011) follow-up. Setting: The setting was an outpatient diabetes clinic. Patients: Fifty-two consecutive subjects (53.8% males; mean age, 37.4 +/- 7.4 y; diabetes duration, 19.9 +/- 8.2 y) with DM1. All participants completed the study. Main Outcome Measures: Main outcome measures were AITD rate; THAb positivity according to hormone interaction and Ig class; association of AITD and THAb with diabetes-related complications. Results: AITD rate increased from baseline (34.6%) to follow-up (38.5%). Subjects with DM1 had a high prevalence of THAb (92.3%). The presence of AITD at baseline was associated with subsequent development of macroangiopathy (0 vs 33% at baseline and follow-up, respectively; P = .029). Some THAb patterns, the majority having T-3 binding in common, were associated with the progression and development of diabetes-related complications. Conclusions: THAb synthesis in DM1 might be driven by increased glycosylation of thyroglobulin. Anti T-3-THAb may cause a relative "tissue hypothyroidism" by sequestering thyroid hormone, this at least partially contributing to worsening diabetes-related vascular complications. In a clinical setting THAb positivity could identify subjects more likely to develop diabetes complications.

Serum thyroid hormone autoantibodies in type 1 diabetes mellitus

BENVENGA, Salvatore
Primo
Writing – Original Draft Preparation
;
PINTAUDI, BASILIO
;
VITA, roberto
Writing – Original Draft Preparation
;
DI VIESTE, GIACOMA;DI BENEDETTO, Antonino
Ultimo
2015-01-01

Abstract

Context: Autoimmune thyroid diseases (AITDs) can be associated with type 1 diabetes (DM1). The prevalence of serum antibodies against thyroid hormones (THAb) in subjects with autoimmune diseases other than DM1 is increasing. No data are available for DM1. Objective: The objectives were evaluate the rate of associated AITD; the rate of positiveness for serum THAb; the panel of THAb based on thyroid hormone interaction and on Ig class; and the association of AITD alone, THAb alone, or AITD plus THAb with diabetes-related complications. Design: This was an observational, prospective study with 6-year (2005-2011) follow-up. Setting: The setting was an outpatient diabetes clinic. Patients: Fifty-two consecutive subjects (53.8% males; mean age, 37.4 +/- 7.4 y; diabetes duration, 19.9 +/- 8.2 y) with DM1. All participants completed the study. Main Outcome Measures: Main outcome measures were AITD rate; THAb positivity according to hormone interaction and Ig class; association of AITD and THAb with diabetes-related complications. Results: AITD rate increased from baseline (34.6%) to follow-up (38.5%). Subjects with DM1 had a high prevalence of THAb (92.3%). The presence of AITD at baseline was associated with subsequent development of macroangiopathy (0 vs 33% at baseline and follow-up, respectively; P = .029). Some THAb patterns, the majority having T-3 binding in common, were associated with the progression and development of diabetes-related complications. Conclusions: THAb synthesis in DM1 might be driven by increased glycosylation of thyroglobulin. Anti T-3-THAb may cause a relative "tissue hypothyroidism" by sequestering thyroid hormone, this at least partially contributing to worsening diabetes-related vascular complications. In a clinical setting THAb positivity could identify subjects more likely to develop diabetes complications.
2015
File in questo prodotto:
File Dimensione Formato  
jcem1870.pdf

solo utenti autorizzati

Tipologia: Versione Editoriale (PDF)
Licenza: Tutti i diritti riservati (All rights reserved)
Dimensione 1.57 MB
Formato Adobe PDF
1.57 MB Adobe PDF   Visualizza/Apri   Richiedi una copia
Pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11570/3068617
Citazioni
  • ???jsp.display-item.citation.pmc??? 9
  • Scopus 21
  • ???jsp.display-item.citation.isi??? 18
social impact