Acetaminophen (N-acetyl-p-aminophenol, APAP) overdosage can produce fatal centrilobular hepatic necrosis in humans. The present study attempted to investigate the protective effect of an anthocyanin-rich extract from bilberries and blackcurrants (AE) against APAP-induced acute hepatic damage in rats. Treatment with AE normalised blood activities of glutamate oxaloacetate and glutamate pyruvate transaminase and prevented APAP-induced plasmatic and tissutal alterations in biomarkers of oxidative stress, probably due to various bioproperties of the components of the extract.
Protective activity of an anthocyanin-rich extract from bilberries and blackcurrants on acute acetaminophen-induced hepatotoxicity in rats
CRISTANI, MariateresaPrimo
;SPECIALE, ANTONIO
Secondo
;MANCARI, FERDINANDO;FERRARI, DANIELA;FRATANTONIO, DEBORAH;SAIJA, Antonina;CIMINO, FrancescoPenultimo
;TROMBETTA, DomenicoUltimo
2016-01-01
Abstract
Acetaminophen (N-acetyl-p-aminophenol, APAP) overdosage can produce fatal centrilobular hepatic necrosis in humans. The present study attempted to investigate the protective effect of an anthocyanin-rich extract from bilberries and blackcurrants (AE) against APAP-induced acute hepatic damage in rats. Treatment with AE normalised blood activities of glutamate oxaloacetate and glutamate pyruvate transaminase and prevented APAP-induced plasmatic and tissutal alterations in biomarkers of oxidative stress, probably due to various bioproperties of the components of the extract.| File | Dimensione | Formato | |
|---|---|---|---|
|
PREPRINT.pdf
solo gestori archivio
Tipologia:
Documento in Pre-print (manoscritto inviato all'editore, precedente alla peer review)
Licenza:
Tutti i diritti riservati (All rights reserved)
Dimensione
785.54 kB
Formato
Adobe PDF
|
785.54 kB | Adobe PDF | Visualizza/Apri Richiedi una copia |
|
Cristani et al 2016 NAT PROD RES Protective activity of an anthocyanin in rats.pdf
solo utenti autorizzati
Descrizione: Verdione Ellettronica
Tipologia:
Versione Editoriale (PDF)
Licenza:
Tutti i diritti riservati (All rights reserved)
Dimensione
665.86 kB
Formato
Adobe PDF
|
665.86 kB | Adobe PDF | Visualizza/Apri Richiedi una copia |
|
3084848.pdf
solo utenti autorizzati
Descrizione: Protective activity of an anthocyanin-rich extract from bilberries and blackcurrants on acute acetaminophen-induced hepatotoxicity in rats
Tipologia:
Versione Editoriale (PDF)
Licenza:
Tutti i diritti riservati (All rights reserved)
Dimensione
2.83 MB
Formato
Adobe PDF
|
2.83 MB | Adobe PDF | Visualizza/Apri Richiedi una copia |
Pubblicazioni consigliate
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
