Huntington disease (HD) is caused by elongated huntingtin (Htt) expressed in all body tissues. However, only one report on a mouse model described enteric neuron abnormalities, i.e. neuropeptides dysfunction [1]. Such kind of abnormalities in human HD, as documented in other neurodegenerative diseases [2], may give us the opportunity to characterize a series of peripheral and gastrointestinal manifestations occurring in this devastating genetic disease [3].

Early enteric neuron dysfunction in mouse and human Huntington disease

Metro, Daniela;
2017

Abstract

Huntington disease (HD) is caused by elongated huntingtin (Htt) expressed in all body tissues. However, only one report on a mouse model described enteric neuron abnormalities, i.e. neuropeptides dysfunction [1]. Such kind of abnormalities in human HD, as documented in other neurodegenerative diseases [2], may give us the opportunity to characterize a series of peripheral and gastrointestinal manifestations occurring in this devastating genetic disease [3].
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11570/3104377
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