Pyridine and pyrimidine derivatives have received great interest in recent pharmacological research, being effective in the treatment of various malignancies, such as myeloid leukemia, breast cancer and idiopathic pulmonary fibrosis. Most of the FDA approved drugs show a pyridine or pyrimidine core bearing different substituents. Aim of this review is to describe the most recent reports in this field, with reference to the new discovered pyridine- or pyrimidine-based drugs, to their synthesis and to the evaluation of the most biologically active derivatives. The corresponding benzofused heterocyclic compounds, i.e. quinolines and quinazolines, are also reported.

Pyridine and Pyrimidine Derivatives as Privileged Scaffolds in Biologically Active Agents

Iannazzo, Daniela
Secondo
;
Romeo, Roberto;Giofrè, Salvatore V
Penultimo
;
2019-01-01

Abstract

Pyridine and pyrimidine derivatives have received great interest in recent pharmacological research, being effective in the treatment of various malignancies, such as myeloid leukemia, breast cancer and idiopathic pulmonary fibrosis. Most of the FDA approved drugs show a pyridine or pyrimidine core bearing different substituents. Aim of this review is to describe the most recent reports in this field, with reference to the new discovered pyridine- or pyrimidine-based drugs, to their synthesis and to the evaluation of the most biologically active derivatives. The corresponding benzofused heterocyclic compounds, i.e. quinolines and quinazolines, are also reported.
2019
File in questo prodotto:
File Dimensione Formato  
3149115.pdf

solo gestori archivio

Descrizione: Pyridine and Pyrimidine Derivatives as Privileged Scaffolds in Biologically Active Agents
Tipologia: Versione Editoriale (PDF)
Licenza: Tutti i diritti riservati (All rights reserved)
Dimensione 14.42 MB
Formato Adobe PDF
14.42 MB Adobe PDF   Visualizza/Apri   Richiedi una copia
Pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11570/3149115
Citazioni
  • ???jsp.display-item.citation.pmc??? 14
  • Scopus 85
  • ???jsp.display-item.citation.isi??? 70
social impact