IRIS
MICALE, Nicola
 Distribuzione geografica
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Continente #
EU - Europa 7.490
NA - Nord America 5.744
AS - Asia 4.056
SA - Sud America 1.461
AF - Africa 133
Continente sconosciuto - Info sul continente non disponibili 9
OC - Oceania 6
AN - Antartide 1
Totale 18.900
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Nazione #
US - Stati Uniti d'America 5.622
RU - Federazione Russa 3.845
SG - Singapore 1.738
BR - Brasile 1.273
IE - Irlanda 1.045
CN - Cina 1.044
SE - Svezia 801
HK - Hong Kong 450
IT - Italia 429
UA - Ucraina 313
VN - Vietnam 296
DE - Germania 291
FR - Francia 188
GB - Regno Unito 176
FI - Finlandia 150
IN - India 131
PL - Polonia 74
AR - Argentina 72
CA - Canada 55
BD - Bangladesh 52
ZA - Sudafrica 48
TR - Turchia 47
IQ - Iraq 44
MX - Messico 37
ID - Indonesia 36
JP - Giappone 35
CZ - Repubblica Ceca 33
ES - Italia 33
EC - Ecuador 31
UZ - Uzbekistan 26
MA - Marocco 25
BE - Belgio 22
NL - Olanda 22
CO - Colombia 20
PK - Pakistan 18
SA - Arabia Saudita 18
TN - Tunisia 16
VE - Venezuela 16
AE - Emirati Arabi Uniti 15
AT - Austria 14
PE - Perù 14
PY - Paraguay 14
PH - Filippine 12
AZ - Azerbaigian 10
OM - Oman 10
DZ - Algeria 9
CL - Cile 8
NP - Nepal 8
EU - Europa 7
KE - Kenya 7
LT - Lituania 7
MY - Malesia 7
UY - Uruguay 7
BO - Bolivia 6
GE - Georgia 6
HN - Honduras 6
IL - Israele 6
JM - Giamaica 6
LB - Libano 6
AL - Albania 5
DO - Repubblica Dominicana 5
ET - Etiopia 5
IR - Iran 5
BH - Bahrain 4
BY - Bielorussia 4
CI - Costa d'Avorio 4
HU - Ungheria 4
LV - Lettonia 4
PA - Panama 4
QA - Qatar 4
RS - Serbia 4
SK - Slovacchia (Repubblica Slovacca) 4
SN - Senegal 4
TW - Taiwan 4
AM - Armenia 3
BG - Bulgaria 3
CH - Svizzera 3
DK - Danimarca 3
GR - Grecia 3
JO - Giordania 3
KR - Corea 3
KZ - Kazakistan 3
PT - Portogallo 3
TT - Trinidad e Tobago 3
AO - Angola 2
AU - Australia 2
EE - Estonia 2
GA - Gabon 2
GT - Guatemala 2
KG - Kirghizistan 2
LA - Repubblica Popolare Democratica del Laos 2
LY - Libia 2
NG - Nigeria 2
NI - Nicaragua 2
NZ - Nuova Zelanda 2
PS - Palestinian Territory 2
RO - Romania 2
TH - Thailandia 2
A2 - ???statistics.table.value.countryCode.A2??? 1
AD - Andorra 1
Totale 18.881
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Città #
Moscow 1.181
Dublin 1.044
Singapore 930
Ashburn 781
Dallas 605
Jacksonville 598
Chandler 554
Nyköping 527
Hong Kong 447
Beijing 391
San Jose 191
The Dalles 191
Princeton 163
Los Angeles 150
Messina 149
Medford 136
Lauterbourg 135
Cambridge 126
Dearborn 121
Des Moines 108
São Paulo 83
New York 78
Boardman 77
Ann Arbor 73
Buffalo 73
Dong Ket 72
Warsaw 70
Ho Chi Minh City 68
Tianjin 57
Hanoi 49
Munich 48
Redondo Beach 47
Rio de Janeiro 43
Lancaster 38
Jinan 36
Guangzhou 34
Belo Horizonte 32
Frankfurt am Main 32
Woodbridge 31
Wilmington 30
Tokyo 29
Orem 27
Santa Clara 27
Seattle 27
Rome 26
Tashkent 26
Johannesburg 25
Chicago 24
Montreal 24
Chennai 23
Curitiba 23
San Mateo 23
Shenyang 23
Brno 22
Milan 22
Pune 22
Shanghai 22
Stockholm 22
Houston 21
Brasília 20
Brooklyn 20
Brussels 20
Shenzhen 20
Nanjing 19
Porto Alegre 19
Council Bluffs 18
Denver 18
Guarulhos 18
London 18
Atlanta 16
Campinas 16
Manaus 16
Hyderabad 15
Nuremberg 15
San Francisco 15
Amsterdam 14
Baghdad 14
Helsinki 14
Mumbai 14
Salvador 14
Boston 13
Norwalk 13
Poplar 13
Ankara 11
Augusta 11
Cape Town 11
Da Nang 11
Quito 11
Zhengzhou 11
Baku 10
Guayaquil 10
Hebei 10
Jakarta 10
Joinville 10
Manchester 10
Nanchang 10
Biên Hòa 9
Hangzhou 9
Mexico City 9
Olomouc 9
Totale 10.621
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Nome #
1-Aryl-6,7-methylenedioxy-3H-quinazolin-4-ones as anticonvulsant agents 253
"Click" on PLGA-PEG and hyaluronic acid: Gaining access to anti-leishmanial pentamidine bioconjugates 203
7,8-methylenedioxy-4H-2,3-benzodiazepin-4-ones as novel AMPA receptor antagonists 197
Antimicrobial and antiprotozoal activities of silver coordination polymers derived from the asymmetric halogenated Schiff base ligands 196
5-Phenyl-9H-1,3-dioxolo[4,5-h][2,3]-benzodiazepin-8(7H)-one 193
A hyaluronic acid–pentamidine bioconjugate as a macrophage mediated drug targeting delivery system for the treatment of leishmaniasis 190
3,5-Dihydro-5-methyl-7,8-methylenedioxy-4H-2,3-benzodiazepin-4-ones as novel noncompetitive AMPA receptor antagonists 177
Discovery of benzimidazole-based Leishmania mexicana cysteine protease CPB2.8ΔCTE inhibitors as potential therapeutics for leishmaniasis 177
Constrained peptidomimetics as antiplasmodial falcipain-2 inhibitors 175
α,α-Difluoromethyl Ketone Moiety: A Promising Functional Group for Targeting Druggable Enzymes 174
Antileukemia Activity and Mechanism of Platinum(II)-Based Metal Complexes 172
Polimorfismi del gene PON1, attività della paraoxonase sierica ed effetti antiossidanti dell’atorvastatina in soggetti del sud Italia 171
4,4-Methylenedioxybenzene derivatives: synthesis and investigation of the mechanism of their anticonvulsant activity. 168
7,9-Dihydro-1,3-dioxolo[4,5-h][2,3]benzodiazepin-8(7H)-ones as anticonvulsant agents 167
Cross-Metathesis Reactions in the Synthesis of Constrained Dipeptide Mimics as Potent Falcipain-2 Inhibitors. 166
Cross-Metathesis Reactions in the Synthesis of Constrained Dipeptide Mimics as Potent Falcipain-2 Inhibitors 162
A simple and efficient synthesis of GYKI 52466 and GYKI 52895 158
DEVELOPMENT OF NOVEL PEPTIDOMIMETIC ANALOGUES OF A HIGHLY POTENT AND SELECTIVE FALCIPAIN-2 INHIBITOR CONTANING A VINYL ESTER MOIETY 156
Design, synthesis and molecular modeling studies on peptidomimetic vinyl esters as falcipan-2 inhibitors 156
Anticancer study of heterobimetallic platinum(II)-ruthenium(II) and platinum(II)-rhodium(III) complexes with bridging dithiooxamide ligand 155
Chloro-substituted Hoveyda-Grubbs ruthenium carbene: Investigation of electronic effects 154
6,7-Methylenedioxyphtalazin-1(2H)-ones as novel and potent anticonvulsant agents 154
Hydroxamic Acid-Based Histone Deacetylase (HDAC) Inhibitors Bearing a Pyrazole Scaffold and a Cinnamoyl Linker 151
Chloro-substituted Hoveyda-Grubbs ruthenium carbene: investigation of electronic effects 150
Hydrogels for the Delivery of Plant-Derived (Poly)Phenols 147
Supramolecular assembly of pentamidine and polymeric cyclodextrin bimetallic core–shell nanoarchitectures 146
6,7-Methylenedioxyquinazolin-4-ones as Anticonvulsant Agents 146
Synthesis, computational investigation and biological evaluation of α,α-difluoromethyl ketones embodying pyrazole and isoxazole nuclei as COX inhibitors 145
4,5-Methylenedioxybenzene derivatives: synthesis and investigation of the mechanism of their anticonvulsant activity. 145
Synthesis, Chiral Resolution and Pharmacological Evaluation of a 2,3-Benzodiazepine-Derived Noncompetitive AMPA Receptor Antagonist 143
6,7-Metilendiossiftalazin-1(2H)-oni: una nuova classe di potenti agenti anticonvulsivanti. 142
6,7-Methylenedioxyphthalazin-1(2H)-ones as novel and potent anticonvulsant agents 142
Antimicrobial peptide capsids of de novo design 142
Falcipain-2 inhibitors 141
Silibinin-conjugated graphene nanoplatform: Synthesis, characterization and biological evaluation 140
Peptide-based α,α-Difluoromethyl Ketone as new inhibitor of Pathogenic Coronavirus Mpro 139
SARS-CoV-2 Mpro: A Potential Target for Peptidomimetics and Small-Molecule Inhibitors 138
Development of Novel Peptidomimetics Containing a VinylSulfone Moiety as Proteasome Inhibitors 138
Novel peptidomimetics containing different α,β-unsaturated electrophilic functions, as falcipain-2 inhibitors 133
Pseudo-Dipeptide Bearing α,α-Difluoromethyl Ketone Moiety as Electrophilic Warhead with Activity against Coronaviruses 133
PREPARATION OF PLA-BASED NANOPARTICLES LOADED WITH SALINOMYCIN AND FOLIC ACID 132
Anticancer activity and morphological analysis of Pt(II) complexes: Their DFT approach, docking simulation, and ADME-Tox profiling 131
2,3-Benzodiazepine-based noncompetitive AMPAR antagonists: design, synthesis, binding affinity and mechanism of inhibition of the GluR2Qflip homomeric receptor channel 130
Cap.21. Antitrombotici 129
Cross-metathesis reactions applications to the synthesis of peptidomimetics as potent falcipain-2 inhibitors 127
Ensemble-based ADME-Tox profiling and virtual screening for the discovery of new inhibitors of the Leishmania mexicana cysteine protease CPB2.8ΔCTE 127
Novel Class of Proteasome Inhibitors: In Silico and In Vitro Evaluation of Diverse Chloro(trifluoromethyl)aziridines 126
Design, synthesis and biological evaluation of peptidomimetics boronic acids targeting 20S proteasome 125
Fluorine-based pseudopeptides from halocarbene transfer reaction: synthesis and biological perspectives 125
Direct and Chemoselective Synthesis of Tertiary Difluoroketones via Weinreb Amide Homologation with a CHF2-Carbene Equivalent 125
Novel Cinnamic Esters as SARS-CoV-2 Mpro Inhibitors with In Vitro Activity against Human Coronaviruses 123
Antibacterial, antioxidant and anti-inflammatory properties of essential oils in combination 122
Peptidomimetics containing a vinyl ketone warhead as falcipain-2 inhibitors 122
Synthesis, Characterization and Biological Profile of Pentamidine-based Nano-antimicrobials 121
Development of peptidomimetic boronates as proteasome inhibitors 121
Development of Novel Selective Peptidomimetics Containing a Boronic Acid Moiety, Targeting the 20S Proteasome as Anticancer Agents 121
Development of peptidomimetic boronates as proteasome inhibitors 120
Direct and chemoselective transfer of the difluoromethyl (CHF2) unit into carbon-electrophiles under nucleophilic regime 120
STRATEGIES FOR SYNTHESIS OF CONFORMATIONALLY CONSTRAINED GLUTAMATE ANALOGUES 119
Glutamate Binding-Site Ligands of NMDA Receptors 119
Copper(II) complexes with tridentate halogen‐substituted Schiff base ligands: synthesis, crystal structures and investigating the effect of halogenation, leaving group and ligand flexibility on antiproliferative activities 119
Synthesis of C3/C1-Substituted Tetrahydroisoquinolines 118
Novel potent AMPA/kainate receptor antagonists: Synthesis and anticonvulsant activity of a series of 2-[(4- alkylsemicarbazono)-(4-aminophenyl)methyl]-4,5- methylenedioxyphenylacetic acid alkyl esters 117
DEVELOPMENT OF NOVEL PEPTIDOMIMETICS CONTAINIG A VINYL SULFONE MOIETY AS PROTEASOME INHIBITORS 117
Mechanism of Inhibition of the GluA2 AMPA Receptor Channel Opening: The Role of 4-Methyl versus 4-Carbonyl Group on the Diazepine Ring of 2,3-Benzodiazepine Derivatives 115
Novel peptidomimetics as antiplasmodial falcipain-2 inhibitors 113
Synthesis and Molecular Modeling Studies of Derivatives of a Highly Potent Peptidomimetic Vinyl Ester as Falcipain-2 Inhibitors 113
Synthesis of α-fluorocinnamate derivatives as novel cathepsin S inhibitors with in vitro antiproliferative activity against pancreatic cancer cells 112
Synthesis of novel peptidomimetics as inhibitors of protozoan cysteine proteases falcipain-2 and rhodesain 112
Structure-activity study of 2,3-benzodiazepin-4-ones noncompetitive AMPAR antagonists: identification of the 1-(4-amino,3-methylphenyl)-3,5-dihydro-7,8-ethylenedioxy-4H-2,3-benzodiazepin-4-one as neuroprotective agent 111
Novel 2H-isoquinolin-3-ones as antiplasmodial falcipain-2 inhibitors 110
Optimization of peptidomimetic boronates bearing a P3 bicyclic scaffold as proteasome inhibitors 110
Reazioni di cross metathesis: applicazione alla sintesi di peptidomimetici potenziali inibitori di falcipaina-2 109
DESIGN, SYNTHESIS AND BIOLOGICAL EVALUATION OF PEPTIDOMIMETIC FALCIPAIN-2 INHIBITORS AS ANTIMALARIAL AGENTS 109
Biological evaluation, DFT, MEP, HOMO-LUMO analysis and ensemble docking studies of Zn(II) complexes of bidentate and tetradentate Schiff base ligands as antileukemia agents 109
Synthesis and anticonvulsant activity of novel and potent 6,7- methylenedioxyphthalazin-1(2H)-ones 108
Synthesis and anticonvulsant activity of novel and potent 1- aryl-7,8-methylenedioxy-1,2,3,5-tetrahydro-4H-2,3- benzodiazepin-4-ones 107
Development of nonpeptidic vinyl and allyl phosphonates as active-site-directed inhibitors of falcipain-2 107
Synthesis of 2-semicarbazonomethyl-4,5-methylenedioxyphenylacetic acids as anticonvulsant agents 106
Synthesis and structure-activity relationship of 2,3-benzodiazepines AMPA receptor antagonists 106
Natural product-based hybrids as potential candidates for the treatment of cancer: Focus on curcumin and resveratrol 106
Synthesis and biological evaluation of new 2-amino-6-(trifluoromethoxy)benzoxazole derivatives, analogues of riluzole. 105
N-Hydroxypyrazolyl Glycine Derivatives as Selective N-Methyl-D-aspartic Acid Receptor Ligands 104
Nonpeptidic Vinyl and Allyl Phosphonates as Falcipain-2 Inhibitors 104
Silibinin conjugated graphene and hyaluronic acid platforms for osteosarcoma targeting 104
Direct and chemoselective synthesis α,α-difluoromethylketones under transfer of (CHF2) unit 104
Novel peptidomimetic cysteine protease inhibitors as potential antimalarial agents 103
Characterization of the binding site in a series of AMPA receptor antagonists. 103
Peptidyl fluoromethyl ketones and their applications in medicinal chemistry 102
Synthesis, chiral resolution and enantiopharmacology of a potent 2,3-benzodiazepine as noncompetitive AMPA receptor antagonist 101
Nuovi derivati dell’acido 4,5-metilendiossi-fenilacetico antagonisti del recettore AMPA/KA. 101
Synthesis and anticonvulsant activity of new 2,3-benzodiazepines as AMPA receptor antagonists 100
Synthesis of constrained dipeptide mimics containing the benzodiazepine scaffold 100
Subunit-specific agonist activity at NR2A, NR2B, NR2C, and NR2D containing N-methyl-D-aspartate glutamate receptors. 100
Synthesis of benzothiazole derivatives and their biological evaluation as anticancer agents 100
Identification of a new series of non-covalent proteasome inhibitors with selectivity for β5-subunits 100
Development of Peptidomimetics with a Vinyl Sulfone Warhead as Irreversible Falcipain-2 Inhibitors 99
Structure-activity relationships of 2,3-benzodiazepines as AMPA/KA receptor antagonists 98
Synthesis and anti-HIV activity evaluation of new phenyl ethyl thiourea (PET) derivatives 98
Physicochemical properties of inclusion complexes of highly soluble β-cyclodextrins with highly hydrophobic testosterone propionate 98
Totale 13.178
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Categoria #
all - tutte 62.293
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 62.293
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021329 0 0 0 0 0 0 0 0 0 162 57 110
2021/2022978 13 169 15 30 19 4 70 40 7 33 249 329
2022/20232.640 208 196 109 185 172 271 43 120 1.237 12 62 25
2023/2024598 42 84 59 147 64 75 5 31 6 20 10 55
2024/20253.290 55 45 105 162 165 60 110 709 848 197 258 576
2025/20268.954 417 738 690 658 764 2.073 1.102 1.123 1.075 314 0 0
Totale 19.270