IRIS
MICALE, Nicola
 Distribuzione geografica
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Continente #
EU - Europa 7.517
NA - Nord America 6.019
AS - Asia 4.105
SA - Sud America 1.462
AF - Africa 134
Continente sconosciuto - Info sul continente non disponibili 9
OC - Oceania 6
AN - Antartide 1
Totale 19.253
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Nazione #
US - Stati Uniti d'America 5.874
RU - Federazione Russa 3.845
SG - Singapore 1.747
BR - Brasile 1.273
CN - Cina 1.065
IE - Irlanda 1.045
SE - Svezia 801
HK - Hong Kong 451
IT - Italia 448
UA - Ucraina 313
VN - Vietnam 297
DE - Germania 293
FR - Francia 190
GB - Regno Unito 178
FI - Finlandia 150
IN - India 136
PL - Polonia 75
AR - Argentina 72
CA - Canada 68
BD - Bangladesh 64
ZA - Sudafrica 48
TR - Turchia 47
IQ - Iraq 44
MX - Messico 37
ID - Indonesia 36
JP - Giappone 35
CZ - Repubblica Ceca 33
ES - Italia 33
EC - Ecuador 31
UZ - Uzbekistan 26
MA - Marocco 25
BE - Belgio 22
NL - Olanda 22
CO - Colombia 20
PK - Pakistan 18
SA - Arabia Saudita 18
TN - Tunisia 16
VE - Venezuela 16
AE - Emirati Arabi Uniti 15
AT - Austria 14
PE - Perù 14
PY - Paraguay 14
PH - Filippine 12
AZ - Azerbaigian 10
OM - Oman 10
DZ - Algeria 9
HN - Honduras 9
CL - Cile 8
JM - Giamaica 8
NP - Nepal 8
UY - Uruguay 8
EU - Europa 7
KE - Kenya 7
LT - Lituania 7
MY - Malesia 7
BO - Bolivia 6
GE - Georgia 6
IL - Israele 6
LB - Libano 6
AL - Albania 5
CI - Costa d'Avorio 5
DO - Repubblica Dominicana 5
ET - Etiopia 5
IR - Iran 5
BH - Bahrain 4
BY - Bielorussia 4
CR - Costa Rica 4
HU - Ungheria 4
LV - Lettonia 4
PA - Panama 4
QA - Qatar 4
RS - Serbia 4
SK - Slovacchia (Repubblica Slovacca) 4
SN - Senegal 4
TW - Taiwan 4
AM - Armenia 3
BG - Bulgaria 3
CH - Svizzera 3
DK - Danimarca 3
GR - Grecia 3
JO - Giordania 3
KR - Corea 3
KZ - Kazakistan 3
PT - Portogallo 3
TT - Trinidad e Tobago 3
AO - Angola 2
AU - Australia 2
BB - Barbados 2
EE - Estonia 2
GA - Gabon 2
GT - Guatemala 2
KG - Kirghizistan 2
LA - Repubblica Popolare Democratica del Laos 2
LY - Libia 2
NG - Nigeria 2
NI - Nicaragua 2
NZ - Nuova Zelanda 2
PS - Palestinian Territory 2
RO - Romania 2
TH - Thailandia 2
Totale 19.232
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Città #
Moscow 1.181
Dublin 1.044
Singapore 935
Ashburn 830
Dallas 606
Jacksonville 599
Chandler 554
Nyköping 527
Hong Kong 448
Beijing 395
San Jose 260
The Dalles 192
Princeton 163
Los Angeles 153
Messina 153
Medford 136
Lauterbourg 135
Cambridge 126
Dearborn 121
Des Moines 108
New York 84
São Paulo 83
Boardman 77
Ann Arbor 73
Buffalo 73
Dong Ket 72
Warsaw 70
Ho Chi Minh City 69
Tianjin 58
Hanoi 49
Munich 48
Redondo Beach 47
Rio de Janeiro 43
Council Bluffs 42
Lancaster 38
Jinan 36
Guangzhou 34
Santa Clara 34
Belo Horizonte 32
Frankfurt am Main 32
Woodbridge 31
Orem 30
Wilmington 30
Tokyo 29
Chicago 27
Seattle 27
Montreal 26
Rome 26
Tashkent 26
Johannesburg 25
Houston 24
Chennai 23
Curitiba 23
San Mateo 23
Shenyang 23
Brno 22
Milan 22
Pune 22
Shanghai 22
Stockholm 22
Brooklyn 21
Brasília 20
Brussels 20
Shenzhen 20
Nanjing 19
Porto Alegre 19
Denver 18
Guarulhos 18
London 18
San Francisco 17
Atlanta 16
Campinas 16
Manaus 16
Hyderabad 15
Nuremberg 15
Amsterdam 14
Baghdad 14
Helsinki 14
Mumbai 14
Salvador 14
Boston 13
Norwalk 13
Poplar 13
Ankara 11
Augusta 11
Cape Town 11
Da Nang 11
Quito 11
Zhengzhou 11
Baku 10
Guayaquil 10
Hebei 10
Jakarta 10
Joinville 10
Manchester 10
Nanchang 10
Biên Hòa 9
Hangzhou 9
Las Vegas 9
Mexico City 9
Totale 10.812
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Nome #
1-Aryl-6,7-methylenedioxy-3H-quinazolin-4-ones as anticonvulsant agents 254
"Click" on PLGA-PEG and hyaluronic acid: Gaining access to anti-leishmanial pentamidine bioconjugates 207
7,8-methylenedioxy-4H-2,3-benzodiazepin-4-ones as novel AMPA receptor antagonists 199
Antimicrobial and antiprotozoal activities of silver coordination polymers derived from the asymmetric halogenated Schiff base ligands 198
5-Phenyl-9H-1,3-dioxolo[4,5-h][2,3]-benzodiazepin-8(7H)-one 196
A hyaluronic acid–pentamidine bioconjugate as a macrophage mediated drug targeting delivery system for the treatment of leishmaniasis 193
α,α-Difluoromethyl Ketone Moiety: A Promising Functional Group for Targeting Druggable Enzymes 190
3,5-Dihydro-5-methyl-7,8-methylenedioxy-4H-2,3-benzodiazepin-4-ones as novel noncompetitive AMPA receptor antagonists 179
Discovery of benzimidazole-based Leishmania mexicana cysteine protease CPB2.8ΔCTE inhibitors as potential therapeutics for leishmaniasis 178
Constrained peptidomimetics as antiplasmodial falcipain-2 inhibitors 177
Antileukemia Activity and Mechanism of Platinum(II)-Based Metal Complexes 176
4,4-Methylenedioxybenzene derivatives: synthesis and investigation of the mechanism of their anticonvulsant activity. 172
Polimorfismi del gene PON1, attività della paraoxonase sierica ed effetti antiossidanti dell’atorvastatina in soggetti del sud Italia 172
7,9-Dihydro-1,3-dioxolo[4,5-h][2,3]benzodiazepin-8(7H)-ones as anticonvulsant agents 168
Cross-Metathesis Reactions in the Synthesis of Constrained Dipeptide Mimics as Potent Falcipain-2 Inhibitors. 168
Cross-Metathesis Reactions in the Synthesis of Constrained Dipeptide Mimics as Potent Falcipain-2 Inhibitors 164
A simple and efficient synthesis of GYKI 52466 and GYKI 52895 159
Chloro-substituted Hoveyda-Grubbs ruthenium carbene: Investigation of electronic effects 158
DEVELOPMENT OF NOVEL PEPTIDOMIMETIC ANALOGUES OF A HIGHLY POTENT AND SELECTIVE FALCIPAIN-2 INHIBITOR CONTANING A VINYL ESTER MOIETY 158
Design, synthesis and molecular modeling studies on peptidomimetic vinyl esters as falcipan-2 inhibitors 157
Anticancer study of heterobimetallic platinum(II)-ruthenium(II) and platinum(II)-rhodium(III) complexes with bridging dithiooxamide ligand 156
6,7-Methylenedioxyphtalazin-1(2H)-ones as novel and potent anticonvulsant agents 155
Hydroxamic Acid-Based Histone Deacetylase (HDAC) Inhibitors Bearing a Pyrazole Scaffold and a Cinnamoyl Linker 153
Supramolecular assembly of pentamidine and polymeric cyclodextrin bimetallic core–shell nanoarchitectures 151
Chloro-substituted Hoveyda-Grubbs ruthenium carbene: investigation of electronic effects 151
Synthesis, computational investigation and biological evaluation of α,α-difluoromethyl ketones embodying pyrazole and isoxazole nuclei as COX inhibitors 149
Hydrogels for the Delivery of Plant-Derived (Poly)Phenols 148
4,5-Methylenedioxybenzene derivatives: synthesis and investigation of the mechanism of their anticonvulsant activity. 147
6,7-Methylenedioxyquinazolin-4-ones as Anticonvulsant Agents 147
Synthesis, Chiral Resolution and Pharmacological Evaluation of a 2,3-Benzodiazepine-Derived Noncompetitive AMPA Receptor Antagonist 144
Falcipain-2 inhibitors 144
6,7-Methylenedioxyphthalazin-1(2H)-ones as novel and potent anticonvulsant agents 144
Antimicrobial peptide capsids of de novo design 144
6,7-Metilendiossiftalazin-1(2H)-oni: una nuova classe di potenti agenti anticonvulsivanti. 143
SARS-CoV-2 Mpro: A Potential Target for Peptidomimetics and Small-Molecule Inhibitors 142
Silibinin-conjugated graphene nanoplatform: Synthesis, characterization and biological evaluation 141
Peptide-based α,α-Difluoromethyl Ketone as new inhibitor of Pathogenic Coronavirus Mpro 141
Development of Novel Peptidomimetics Containing a VinylSulfone Moiety as Proteasome Inhibitors 139
Novel peptidomimetics containing different α,β-unsaturated electrophilic functions, as falcipain-2 inhibitors 135
PREPARATION OF PLA-BASED NANOPARTICLES LOADED WITH SALINOMYCIN AND FOLIC ACID 135
Pseudo-Dipeptide Bearing α,α-Difluoromethyl Ketone Moiety as Electrophilic Warhead with Activity against Coronaviruses 135
Anticancer activity and morphological analysis of Pt(II) complexes: Their DFT approach, docking simulation, and ADME-Tox profiling 133
Novel Cinnamic Esters as SARS-CoV-2 Mpro Inhibitors with In Vitro Activity against Human Coronaviruses 130
Novel Class of Proteasome Inhibitors: In Silico and In Vitro Evaluation of Diverse Chloro(trifluoromethyl)aziridines 130
Cap.21. Antitrombotici 130
2,3-Benzodiazepine-based noncompetitive AMPAR antagonists: design, synthesis, binding affinity and mechanism of inhibition of the GluR2Qflip homomeric receptor channel 130
Cross-metathesis reactions applications to the synthesis of peptidomimetics as potent falcipain-2 inhibitors 129
Antibacterial, antioxidant and anti-inflammatory properties of essential oils in combination 128
Ensemble-based ADME-Tox profiling and virtual screening for the discovery of new inhibitors of the Leishmania mexicana cysteine protease CPB2.8ΔCTE 128
Design, synthesis and biological evaluation of peptidomimetics boronic acids targeting 20S proteasome 126
Direct and Chemoselective Synthesis of Tertiary Difluoroketones via Weinreb Amide Homologation with a CHF2-Carbene Equivalent 126
Synthesis, Characterization and Biological Profile of Pentamidine-based Nano-antimicrobials 125
Fluorine-based pseudopeptides from halocarbene transfer reaction: synthesis and biological perspectives 125
Development of Novel Selective Peptidomimetics Containing a Boronic Acid Moiety, Targeting the 20S Proteasome as Anticancer Agents 124
Development of peptidomimetic boronates as proteasome inhibitors 123
STRATEGIES FOR SYNTHESIS OF CONFORMATIONALLY CONSTRAINED GLUTAMATE ANALOGUES 122
Peptidomimetics containing a vinyl ketone warhead as falcipain-2 inhibitors 122
Glutamate Binding-Site Ligands of NMDA Receptors 121
Development of peptidomimetic boronates as proteasome inhibitors 121
Copper(II) complexes with tridentate halogen‐substituted Schiff base ligands: synthesis, crystal structures and investigating the effect of halogenation, leaving group and ligand flexibility on antiproliferative activities 121
Direct and chemoselective transfer of the difluoromethyl (CHF2) unit into carbon-electrophiles under nucleophilic regime 120
Synthesis of C3/C1-Substituted Tetrahydroisoquinolines 120
Novel potent AMPA/kainate receptor antagonists: Synthesis and anticonvulsant activity of a series of 2-[(4- alkylsemicarbazono)-(4-aminophenyl)methyl]-4,5- methylenedioxyphenylacetic acid alkyl esters 117
DEVELOPMENT OF NOVEL PEPTIDOMIMETICS CONTAINIG A VINYL SULFONE MOIETY AS PROTEASOME INHIBITORS 117
Mechanism of Inhibition of the GluA2 AMPA Receptor Channel Opening: The Role of 4-Methyl versus 4-Carbonyl Group on the Diazepine Ring of 2,3-Benzodiazepine Derivatives 116
DESIGN, SYNTHESIS AND BIOLOGICAL EVALUATION OF PEPTIDOMIMETIC FALCIPAIN-2 INHIBITORS AS ANTIMALARIAL AGENTS 114
Synthesis and Molecular Modeling Studies of Derivatives of a Highly Potent Peptidomimetic Vinyl Ester as Falcipain-2 Inhibitors 114
Synthesis of α-fluorocinnamate derivatives as novel cathepsin S inhibitors with in vitro antiproliferative activity against pancreatic cancer cells 113
Synthesis of novel peptidomimetics as inhibitors of protozoan cysteine proteases falcipain-2 and rhodesain 113
Novel peptidomimetics as antiplasmodial falcipain-2 inhibitors 113
Reazioni di cross metathesis: applicazione alla sintesi di peptidomimetici potenziali inibitori di falcipaina-2 112
Optimization of peptidomimetic boronates bearing a P3 bicyclic scaffold as proteasome inhibitors 112
Biological evaluation, DFT, MEP, HOMO-LUMO analysis and ensemble docking studies of Zn(II) complexes of bidentate and tetradentate Schiff base ligands as antileukemia agents 112
Structure-activity study of 2,3-benzodiazepin-4-ones noncompetitive AMPAR antagonists: identification of the 1-(4-amino,3-methylphenyl)-3,5-dihydro-7,8-ethylenedioxy-4H-2,3-benzodiazepin-4-one as neuroprotective agent 111
Synthesis and anticonvulsant activity of novel and potent 6,7- methylenedioxyphthalazin-1(2H)-ones 110
Novel 2H-isoquinolin-3-ones as antiplasmodial falcipain-2 inhibitors 110
Development of nonpeptidic vinyl and allyl phosphonates as active-site-directed inhibitors of falcipain-2 108
Synthesis and biological evaluation of new 2-amino-6-(trifluoromethoxy)benzoxazole derivatives, analogues of riluzole. 108
Natural product-based hybrids as potential candidates for the treatment of cancer: Focus on curcumin and resveratrol 108
Synthesis of 2-semicarbazonomethyl-4,5-methylenedioxyphenylacetic acids as anticonvulsant agents 107
Synthesis and anticonvulsant activity of novel and potent 1- aryl-7,8-methylenedioxy-1,2,3,5-tetrahydro-4H-2,3- benzodiazepin-4-ones 107
N-Hydroxypyrazolyl Glycine Derivatives as Selective N-Methyl-D-aspartic Acid Receptor Ligands 106
Silibinin conjugated graphene and hyaluronic acid platforms for osteosarcoma targeting 106
Synthesis and structure-activity relationship of 2,3-benzodiazepines AMPA receptor antagonists 106
Characterization of the binding site in a series of AMPA receptor antagonists. 105
Nonpeptidic Vinyl and Allyl Phosphonates as Falcipain-2 Inhibitors 105
Novel peptidomimetic cysteine protease inhibitors as potential antimalarial agents 104
Synthesis, chiral resolution and enantiopharmacology of a potent 2,3-benzodiazepine as noncompetitive AMPA receptor antagonist 104
Direct and chemoselective synthesis α,α-difluoromethylketones under transfer of (CHF2) unit 104
Subunit-specific agonist activity at NR2A, NR2B, NR2C, and NR2D containing N-methyl-D-aspartate glutamate receptors. 103
Synthesis of benzothiazole derivatives and their biological evaluation as anticancer agents 103
SYNTHESIS OF PYRAZOLE DERIVATIVES DESIGNED AS POTENTIAL INHIBITORS OF DIFFERENT HDAC ISOFORMS 103
Peptidyl fluoromethyl ketones and their applications in medicinal chemistry 103
Nuovi derivati dell’acido 4,5-metilendiossi-fenilacetico antagonisti del recettore AMPA/KA. 102
Development of Peptidomimetics with a Vinyl Sulfone Warhead as Irreversible Falcipain-2 Inhibitors 101
Synthesis and anticonvulsant activity of new 2,3-benzodiazepines as AMPA receptor antagonists 100
Structure-activity relationships of 2,3-benzodiazepines as AMPA/KA receptor antagonists 100
Synthesis of constrained dipeptide mimics containing the benzodiazepine scaffold 100
Identification of a new series of non-covalent proteasome inhibitors with selectivity for β5-subunits 100
Physicochemical properties of inclusion complexes of highly soluble β-cyclodextrins with highly hydrophobic testosterone propionate 100
Totale 13.378
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Categoria #
all - tutte 65.722
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 65.722
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021110 0 0 0 0 0 0 0 0 0 0 0 110
2021/2022978 13 169 15 30 19 4 70 40 7 33 249 329
2022/20232.640 208 196 109 185 172 271 43 120 1.237 12 62 25
2023/2024598 42 84 59 147 64 75 5 31 6 20 10 55
2024/20253.290 55 45 105 162 165 60 110 709 848 197 258 576
2025/20269.309 417 738 690 658 764 2.073 1.102 1.123 1.075 360 184 125
Totale 19.625