IRIS
MICALE, Nicola
 Distribuzione geografica
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Continente #
NA - Nord America 5.096
EU - Europa 3.531
AS - Asia 3.159
SA - Sud America 1.383
AF - Africa 97
Continente sconosciuto - Info sul continente non disponibili 9
OC - Oceania 5
AN - Antartide 1
Totale 13.281
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Nazione #
US - Stati Uniti d'America 4.989
SG - Singapore 1.379
BR - Brasile 1.231
IE - Irlanda 1.043
SE - Svezia 799
CN - Cina 748
HK - Hong Kong 435
IT - Italia 394
UA - Ucraina 313
DE - Germania 262
VN - Vietnam 251
GB - Regno Unito 156
RU - Federazione Russa 156
FI - Finlandia 150
IN - India 86
PL - Polonia 67
AR - Argentina 59
CA - Canada 47
ZA - Sudafrica 40
BD - Bangladesh 37
MX - Messico 34
TR - Turchia 33
CZ - Repubblica Ceca 32
ID - Indonesia 31
IQ - Iraq 31
ES - Italia 30
FR - Francia 30
EC - Ecuador 27
BE - Belgio 21
UZ - Uzbekistan 21
MA - Marocco 18
NL - Olanda 17
CO - Colombia 16
JP - Giappone 16
TN - Tunisia 13
VE - Venezuela 13
AT - Austria 12
PK - Pakistan 12
PY - Paraguay 11
AE - Emirati Arabi Uniti 10
AZ - Azerbaigian 10
PE - Perù 10
CL - Cile 7
EU - Europa 7
LT - Lituania 7
NP - Nepal 7
UY - Uruguay 7
DZ - Algeria 6
HN - Honduras 6
IL - Israele 6
DO - Repubblica Dominicana 5
GE - Georgia 5
OM - Oman 5
AL - Albania 4
BY - Bielorussia 4
CI - Costa d'Avorio 4
HU - Ungheria 4
IR - Iran 4
JM - Giamaica 4
KE - Kenya 4
LV - Lettonia 4
PA - Panama 4
RS - Serbia 4
SN - Senegal 4
AM - Armenia 3
CH - Svizzera 3
DK - Danimarca 3
GR - Grecia 3
JO - Giordania 3
LB - Libano 3
MY - Malesia 3
PT - Portogallo 3
TT - Trinidad e Tobago 3
AO - Angola 2
BG - Bulgaria 2
BH - Bahrain 2
BO - Bolivia 2
EE - Estonia 2
GT - Guatemala 2
KG - Kirghizistan 2
KZ - Kazakistan 2
LA - Repubblica Popolare Democratica del Laos 2
NZ - Nuova Zelanda 2
PH - Filippine 2
QA - Qatar 2
RO - Romania 2
SA - Arabia Saudita 2
SK - Slovacchia (Repubblica Slovacca) 2
A2 - ???statistics.table.value.countryCode.A2??? 1
AD - Andorra 1
AQ - Antartide 1
AU - Australia 1
BB - Barbados 1
BN - Brunei Darussalam 1
BW - Botswana 1
CR - Costa Rica 1
EG - Egitto 1
ET - Etiopia 1
KR - Corea 1
LK - Sri Lanka 1
Totale 13.271
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Città #
Dublin 1.042
Singapore 605
Dallas 599
Jacksonville 596
Ashburn 567
Chandler 554
Nyköping 527
Hong Kong 434
Beijing 381
Princeton 163
Messina 145
Los Angeles 142
Medford 136
Cambridge 126
Dearborn 121
The Dalles 117
Des Moines 107
São Paulo 78
Boardman 76
Ann Arbor 73
Buffalo 73
Dong Ket 72
Warsaw 65
New York 64
Ho Chi Minh City 57
Munich 48
Redondo Beach 47
Rio de Janeiro 42
Lancaster 38
Jinan 36
Belo Horizonte 32
Moscow 32
Woodbridge 31
Hanoi 30
Wilmington 30
Tianjin 29
Seattle 25
Curitiba 23
San Mateo 23
Shenyang 23
Brno 22
Johannesburg 22
Pune 21
Rome 21
Santa Clara 21
Tashkent 21
Brasília 20
Brooklyn 20
Brussels 20
Milan 20
Montreal 20
Stockholm 20
Nanjing 19
Chicago 18
Guarulhos 18
Houston 18
Porto Alegre 17
London 16
Manaus 16
Hyderabad 15
Campinas 14
Helsinki 14
Salvador 14
San Francisco 14
Denver 13
Norwalk 13
Poplar 13
Tokyo 13
Atlanta 11
Augusta 11
Boston 11
Chennai 11
Nuremberg 11
Ankara 10
Baku 10
Cape Town 10
Da Nang 10
Guayaquil 10
Hebei 10
Nanchang 10
Zhengzhou 10
Amsterdam 9
Baghdad 9
Biên Hòa 9
Frankfurt am Main 9
Hangzhou 9
Jakarta 9
Mumbai 9
Olomouc 9
Orem 9
Taizhou 9
Clearwater 8
Haikou 8
Joinville 8
Mexico City 8
Ningbo 8
Quito 8
Vienna 8
Betim 7
Düsseldorf 7
Totale 8.197
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Nome #
1-Aryl-6,7-methylenedioxy-3H-quinazolin-4-ones as anticonvulsant agents 199
7,8-methylenedioxy-4H-2,3-benzodiazepin-4-ones as novel AMPA receptor antagonists 140
Polimorfismi del gene PON1, attività della paraoxonase sierica ed effetti antiossidanti dell’atorvastatina in soggetti del sud Italia 137
A hyaluronic acid–pentamidine bioconjugate as a macrophage mediated drug targeting delivery system for the treatment of leishmaniasis 137
"Click" on PLGA-PEG and hyaluronic acid: Gaining access to anti-leishmanial pentamidine bioconjugates 137
5-Phenyl-9H-1,3-dioxolo[4,5-h][2,3]-benzodiazepin-8(7H)-one 128
Antimicrobial and antiprotozoal activities of silver coordination polymers derived from the asymmetric halogenated Schiff base ligands 128
3,5-Dihydro-5-methyl-7,8-methylenedioxy-4H-2,3-benzodiazepin-4-ones as novel noncompetitive AMPA receptor antagonists 124
Cross-Metathesis Reactions in the Synthesis of Constrained Dipeptide Mimics as Potent Falcipain-2 Inhibitors. 119
Constrained peptidomimetics as antiplasmodial falcipain-2 inhibitors 119
Discovery of benzimidazole-based Leishmania mexicana cysteine protease CPB2.8ΔCTE inhibitors as potential therapeutics for leishmaniasis 118
Design, synthesis and molecular modeling studies on peptidomimetic vinyl esters as falcipan-2 inhibitors 116
Antimicrobial peptide capsids of de novo design 116
Silibinin-conjugated graphene nanoplatform: Synthesis, characterization and biological evaluation 115
DEVELOPMENT OF NOVEL PEPTIDOMIMETIC ANALOGUES OF A HIGHLY POTENT AND SELECTIVE FALCIPAIN-2 INHIBITOR CONTANING A VINYL ESTER MOIETY 114
7,9-Dihydro-1,3-dioxolo[4,5-h][2,3]benzodiazepin-8(7H)-ones as anticonvulsant agents 113
4,4-Methylenedioxybenzene derivatives: synthesis and investigation of the mechanism of their anticonvulsant activity. 112
α,α-Difluoromethyl Ketone Moiety: A Promising Functional Group for Targeting Druggable Enzymes 111
A simple and efficient synthesis of GYKI 52466 and GYKI 52895 109
Cross-Metathesis Reactions in the Synthesis of Constrained Dipeptide Mimics as Potent Falcipain-2 Inhibitors 109
6,7-Methylenedioxyphtalazin-1(2H)-ones as novel and potent anticonvulsant agents 107
Antileukemia Activity and Mechanism of Platinum(II)-Based Metal Complexes 103
Peptidomimetics containing a vinyl ketone warhead as falcipain-2 inhibitors 102
Chloro-substituted Hoveyda-Grubbs ruthenium carbene: investigation of electronic effects 101
Novel peptidomimetics containing different α,β-unsaturated electrophilic functions, as falcipain-2 inhibitors 100
Ensemble-based ADME-Tox profiling and virtual screening for the discovery of new inhibitors of the Leishmania mexicana cysteine protease CPB2.8ΔCTE 100
Anticancer study of heterobimetallic platinum(II)-ruthenium(II) and platinum(II)-rhodium(III) complexes with bridging dithiooxamide ligand 100
Development of Novel Peptidomimetics Containing a VinylSulfone Moiety as Proteasome Inhibitors 99
4,5-Methylenedioxybenzene derivatives: synthesis and investigation of the mechanism of their anticonvulsant activity. 98
6,7-Methylenedioxyquinazolin-4-ones as Anticonvulsant Agents 98
Supramolecular assembly of pentamidine and polymeric cyclodextrin bimetallic core–shell nanoarchitectures 97
Novel potent AMPA/kainate receptor antagonists: Synthesis and anticonvulsant activity of a series of 2-[(4- alkylsemicarbazono)-(4-aminophenyl)methyl]-4,5- methylenedioxyphenylacetic acid alkyl esters 95
Falcipain-2 inhibitors 95
Hydroxamic Acid-Based Histone Deacetylase (HDAC) Inhibitors Bearing a Pyrazole Scaffold and a Cinnamoyl Linker 95
Peptide-based α,α-Difluoromethyl Ketone as new inhibitor of Pathogenic Coronavirus Mpro 93
Synthesis of C3/C1-Substituted Tetrahydroisoquinolines 93
6,7-Metilendiossiftalazin-1(2H)-oni: una nuova classe di potenti agenti anticonvulsivanti. 92
N-Hydroxypyrazolyl Glycine Derivatives as Selective N-Methyl-D-aspartic Acid Receptor Ligands 91
Design, synthesis and biological evaluation of peptidomimetics boronic acids targeting 20S proteasome 91
Pseudo-Dipeptide Bearing α,α-Difluoromethyl Ketone Moiety as Electrophilic Warhead with Activity against Coronaviruses 91
SARS-CoV-2 Mpro: A Potential Target for Peptidomimetics and Small-Molecule Inhibitors 91
Synthesis, Chiral Resolution and Pharmacological Evaluation of a 2,3-Benzodiazepine-Derived Noncompetitive AMPA Receptor Antagonist 90
Synthesis, computational investigation and biological evaluation of α,α-difluoromethyl ketones embodying pyrazole and isoxazole nuclei as COX inhibitors 89
Synthesis and anticonvulsant activity of novel and potent 1- aryl-7,8-methylenedioxy-1,2,3,5-tetrahydro-4H-2,3- benzodiazepin-4-ones 89
STRATEGIES FOR SYNTHESIS OF CONFORMATIONALLY CONSTRAINED GLUTAMATE ANALOGUES 89
Hydrogels for the Delivery of Plant-Derived (Poly)Phenols 89
Synthesis and anticonvulsant activity of novel and potent 6,7- methylenedioxyphthalazin-1(2H)-ones 88
Reazioni di cross metathesis: applicazione alla sintesi di peptidomimetici potenziali inibitori di falcipaina-2 88
Chloro-substituted Hoveyda-Grubbs ruthenium carbene: Investigation of electronic effects 88
Structure-activity study of 2,3-benzodiazepin-4-ones noncompetitive AMPAR antagonists: identification of the 1-(4-amino,3-methylphenyl)-3,5-dihydro-7,8-ethylenedioxy-4H-2,3-benzodiazepin-4-one as neuroprotective agent 88
PREPARATION OF PLA-BASED NANOPARTICLES LOADED WITH SALINOMYCIN AND FOLIC ACID 88
Fluorine-based pseudopeptides from halocarbene transfer reaction: synthesis and biological perspectives 88
Synthesis of 2-semicarbazonomethyl-4,5-methylenedioxyphenylacetic acids as anticonvulsant agents 87
6,7-Methylenedioxyphthalazin-1(2H)-ones as novel and potent anticonvulsant agents 87
Mechanism of Inhibition of the GluA2 AMPA Receptor Channel Opening: The Role of 4-Methyl versus 4-Carbonyl Group on the Diazepine Ring of 2,3-Benzodiazepine Derivatives 86
Development of peptidomimetic boronates as proteasome inhibitors 86
Characterization of the binding site in a series of AMPA receptor antagonists. 85
Synthesis and structure-activity relationship of 2,3-benzodiazepines AMPA receptor antagonists 85
DEVELOPMENT OF NOVEL PEPTIDOMIMETICS CONTAINIG A VINYL SULFONE MOIETY AS PROTEASOME INHIBITORS 84
DESIGN, SYNTHESIS AND BIOLOGICAL EVALUATION OF PEPTIDOMIMETIC FALCIPAIN-2 INHIBITORS AS ANTIMALARIAL AGENTS 84
Novel Cinnamic Esters as SARS-CoV-2 Mpro Inhibitors with In Vitro Activity against Human Coronaviruses 83
Subunit-specific agonist activity at NR2A, NR2B, NR2C, and NR2D containing N-methyl-D-aspartate glutamate receptors. 83
Synthesis and anticonvulsant activity of novel and potent 2,3- benzodiazepine AMPA/kainate receptor antagonists 82
Synthesis of novel peptidomimetics as inhibitors of protozoan cysteine proteases falcipain-2 and rhodesain 82
Silibinin conjugated graphene and hyaluronic acid platforms for osteosarcoma targeting 82
2,3-Benzodiazepine-based noncompetitive AMPAR antagonists: design, synthesis, binding affinity and mechanism of inhibition of the GluR2Qflip homomeric receptor channel 82
Synthesis and biological evaluation of new 2-amino-6-(trifluoromethoxy)benzoxazole derivatives, analogues of riluzole. 81
Direct and chemoselective transfer of the difluoromethyl (CHF2) unit into carbon-electrophiles under nucleophilic regime 81
Structure-activity relationships of 2,3-benzodiazepines as AMPA/KA receptor antagonists 80
Synthesis, chiral resolution and enantiopharmacology of a potent 2,3-benzodiazepine as noncompetitive AMPA receptor antagonist 80
Glutamate Binding-Site Ligands of NMDA Receptors 80
Development of peptidomimetic boronates as proteasome inhibitors 80
Direct and Chemoselective Synthesis of Tertiary Difluoroketones via Weinreb Amide Homologation with a CHF2-Carbene Equivalent 80
Nuovi derivati dell’acido 4,5-metilendiossi-fenilacetico antagonisti del recettore AMPA/KA. 79
Development of Novel Selective Peptidomimetics Containing a Boronic Acid Moiety, Targeting the 20S Proteasome as Anticancer Agents 79
Development of Peptidomimetics with a Vinyl Sulfone Warhead as Irreversible Falcipain-2 Inhibitors 77
Copper(II) complexes with tridentate halogen‐substituted Schiff base ligands: synthesis, crystal structures and investigating the effect of halogenation, leaving group and ligand flexibility on antiproliferative activities 77
Synthesis and Molecular Modeling Studies of Derivatives of a Highly Potent Peptidomimetic Vinyl Ester as Falcipain-2 Inhibitors 77
Synthesis, Characterization and Biological Profile of Pentamidine-based Nano-antimicrobials 76
Synthesis and anticonvulsant activity of new 2,3-benzodiazepines as AMPA receptor antagonists 76
Characterization of the mechanism of anticonvulsant activity for a selected set of putative AMPA receptor antagonists 76
Synthesis and in vitro antitumour activity evaluation of 1-aryl-1H,3H-thiazolo[4,3-b]-quinazolines 76
Novel peptidomimetic cysteine protease inhibitors as potential antimalarial agents 76
Development of nonpeptidic vinyl and allyl phosphonates as active-site-directed inhibitors of falcipain-2 76
Novel 2H-isoquinolin-3-ones as antiplasmodial falcipain-2 inhibitors 76
Synthesis of Nanoterapeutics based on G/HA platforms for osteosarcoma targeting. 76
Synthesis and antitumor activity of 1,3-benzodioxole derivatives 75
Synthesis of 5-substituted 7,9-dihydro-8H-[1,3]dioxolo[4,5-h][2,3]benzodiazepin-8-ones as anticonvulsant agents 75
Nonpeptidic Vinyl and Allyl Phosphonates as Falcipain-2 Inhibitors 75
Novel peptidomimetics as antiplasmodial falcipain-2 inhibitors 75
Synthesis of constrained dipeptide mimics containing the benzodiazepine scaffold 74
Progettazione e sintesi di nuovi antagonisti noncompetitivi del recettore AMPA 74
Synthesis and anti-HIV activity evaluation of new phenyl ethyl thiourea (PET) derivatives 74
Cross-metathesis reactions applications to the synthesis of peptidomimetics as potent falcipain-2 inhibitors 74
Novel Class of Proteasome Inhibitors: In Silico and In Vitro Evaluation of Diverse Chloro(trifluoromethyl)aziridines 73
New 7,8-ethylenedioxy-2,3-benzodiazepines as noncompetitive AMPA receptor antagonists 73
Structure-activity relationships of 2,3-benzodiazepines as AMPA/KA receptor antagonists. 73
Novel peptidomimetic cysteine protease inhibitors as antimalarial agents 73
Optimization of peptidomimetic boronates bearing a P3 bicyclic scaffold as proteasome inhibitors 73
Synthesis of Peptidomimetics with the Benzodiazepine Nucleus as beta-turn mimic 73
Totale 9.278
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Categoria #
all - tutte 53.553
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 53.553
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021551 0 0 0 0 0 99 16 83 24 162 57 110
2021/2022978 13 169 15 30 19 4 70 40 7 33 249 329
2022/20232.640 208 196 109 185 172 271 43 120 1.237 12 62 25
2023/2024598 42 84 59 147 64 75 5 31 6 20 10 55
2024/20253.290 55 45 105 162 165 60 110 709 848 197 258 576
2025/20263.334 417 738 690 658 764 67 0 0 0 0 0 0
Totale 13.650