IRIS
ZAPPALA', Maria
 Distribuzione geografica
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Continente #
NA - Nord America 20.865
EU - Europa 14.747
AS - Asia 7.713
SA - Sud America 2.557
AF - Africa 235
Continente sconosciuto - Info sul continente non disponibili 10
OC - Oceania 10
AN - Antartide 1
Totale 46.138
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Nazione #
US - Stati Uniti d'America 20.622
RU - Federazione Russa 7.474
SG - Singapore 3.160
BR - Brasile 2.218
CN - Cina 2.073
IE - Irlanda 1.787
SE - Svezia 1.496
VN - Vietnam 913
UA - Ucraina 871
HK - Hong Kong 781
IT - Italia 751
DE - Germania 708
FR - Francia 429
GB - Regno Unito 393
FI - Finlandia 341
IN - India 188
AT - Austria 133
AR - Argentina 114
CA - Canada 110
BD - Bangladesh 89
PL - Polonia 82
MX - Messico 81
TR - Turchia 73
IQ - Iraq 70
ZA - Sudafrica 58
NL - Olanda 57
CZ - Repubblica Ceca 51
MA - Marocco 51
EC - Ecuador 49
UZ - Uzbekistan 48
BE - Belgio 46
CO - Colombia 46
JP - Giappone 40
ID - Indonesia 35
PK - Pakistan 35
VE - Venezuela 35
CL - Cile 27
ES - Italia 27
TN - Tunisia 26
CI - Costa d'Avorio 22
PY - Paraguay 20
SA - Arabia Saudita 20
IR - Iran 19
PE - Perù 19
AE - Emirati Arabi Uniti 18
UY - Uruguay 18
DZ - Algeria 17
NP - Nepal 16
AZ - Azerbaigian 15
JM - Giamaica 14
GE - Georgia 13
KE - Kenya 13
LT - Lituania 13
MY - Malesia 13
IL - Israele 12
JO - Giordania 12
LV - Lettonia 12
EG - Egitto 11
BO - Bolivia 10
CH - Svizzera 10
KG - Kirghizistan 10
SN - Senegal 10
AL - Albania 8
EU - Europa 8
HN - Honduras 8
KZ - Kazakistan 8
AU - Australia 7
LB - Libano 7
PA - Panama 7
RO - Romania 7
BY - Bielorussia 6
KR - Corea 6
TT - Trinidad e Tobago 6
BA - Bosnia-Erzegovina 5
DO - Repubblica Dominicana 5
KW - Kuwait 5
OM - Oman 5
RS - Serbia 5
SY - Repubblica araba siriana 5
AM - Armenia 4
ET - Etiopia 4
GR - Grecia 4
LU - Lussemburgo 4
ML - Mali 4
MU - Mauritius 4
PH - Filippine 4
TH - Thailandia 4
AO - Angola 3
BG - Bulgaria 3
CR - Costa Rica 3
DK - Danimarca 3
EE - Estonia 3
GA - Gabon 3
HU - Ungheria 3
MD - Moldavia 3
NI - Nicaragua 3
PT - Portogallo 3
BN - Brunei Darussalam 2
CG - Congo 2
CY - Cipro 2
Totale 46.101
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Città #
Dallas 10.038
Moscow 2.313
Dublin 1.786
Singapore 1.692
Jacksonville 1.632
Chandler 1.329
Ashburn 1.328
Nyköping 999
Hong Kong 778
Beijing 711
Dong Ket 554
San Jose 484
Princeton 326
The Dalles 301
Medford 300
Cambridge 283
Los Angeles 274
Lauterbourg 271
Dearborn 260
Des Moines 231
Messina 221
Boardman 183
Ann Arbor 169
São Paulo 146
Buffalo 137
New York 122
Vienna 120
Ho Chi Minh City 118
Tianjin 114
Lancaster 96
Hanoi 88
Munich 88
Council Bluffs 87
Guangzhou 78
Redondo Beach 78
Jinan 76
Warsaw 76
Milan 75
San Mateo 73
Rio de Janeiro 69
Wilmington 69
Woodbridge 61
Belo Horizonte 60
Santa Clara 55
Brooklyn 52
Frankfurt am Main 51
Nanjing 51
Shenyang 50
Orem 48
Tashkent 46
Houston 44
Brno 43
Chicago 43
Montreal 42
Amsterdam 40
Brussels 39
Shanghai 36
Brasília 35
Hyderabad 35
Stockholm 35
Curitiba 33
Haikou 33
Johannesburg 33
Porto Alegre 33
Shenzhen 33
San Francisco 32
Zhengzhou 32
Hebei 30
London 30
Tokyo 30
Baghdad 28
Chennai 28
Pune 28
Campinas 27
Helsinki 27
Seattle 27
Denver 26
Poplar 26
Augusta 25
Atlanta 24
Mumbai 23
Phoenix 23
Rome 23
Taizhou 23
Abidjan 22
Boston 22
Nuremberg 22
Ningbo 21
Turku 21
Aversa 20
Mexico City 20
Nanchang 20
Fuzhou 19
Manchester 19
Norwalk 19
Dhaka 18
Hangzhou 18
Manaus 18
Quito 18
Salvador 18
Totale 30.031
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Nome #
[1,2,4]Oxadiazolo[5,4-d][1,5]benzothiazepines: synthesis and stereochemistry 4.729
[1,2,4]Oxadiazolo[5,4-d][1,5]benzothiazepines: stereochemistry and anticonvulsant activity 4.709
1-[3,5-bis(trifluoromethyl)phenyl]-1H,3H-thiazolo[3,4- a]benzimidazole 299
1-aryl-3,5-dihydro-4H-2,3-benzodiazepin-4-ones: Novel AMPA receptor antagonists 298
1-Phenyl-substituted 1H,3H-thiazolo[3,4-a]benzimidazoles and pharmaceutical compositions containing them 291
1,3-Thiazolidin-4-ones: potent and selective anti-HIV-1 agents 271
1-Aryl-3,5-dihydro-4H-2,3-benzodiazepin-4-ones: non-competitive AMPA receptors antagonists 270
1-Aryl-6,7-methylenedioxy-3H-quinazolin-4-ones as anticonvulsant agents 254
1-Adamantanamine derivatives as potential anti-HIV agents 250
1H,3H-Thiazolo[3,4-a]benzimidazoles and pharmaceutical compositions containing them 240
4,5-Dihydro-7,8-dimethoxy-1-phenyl-3H-2,3-benzodiazepin-4-one 211
3,5-dihydro-4H-2,3-benzodiazepine-4-thiones: A new class of AMPA receptor antagonists 210
2-(2,6-dihalophenyl)-3-(pyrimidin-2-yl)-1,3-thiazolidin-4-ones as non-nucleoside HIV-1 reverse transcriptase inhibitors 202
7,8-methylenedioxy-4H-2,3-benzodiazepin-4-ones as novel AMPA receptor antagonists 199
2,3,3a,4-Tetraidro-1H-pirrolo[1,2-a]benzimidazol-1-oni 3a-sostituiti 198
3H-AZIRINO[1,2-D][1,4]BENZODIAZEPIN-4 (5H)-ONES - SYNTHESIS AND STEREOCHEMISTRY 192
5H-[1,2,4]Oxadiazolo[5,4-d][1,5]benzothiazepines as anticonvulsant agents in DBA/2 mice. 192
Design, synthesis and biological evaluation of novel rhodesain inhibitors for the treatment of Human African Trypanosomiasis 191
5H-[1,2,4]OXADIAZOLO[5,4-D][1,5]BENZOTHIAZEPINES - SYNTHESIS AND STEREOCHEMISTRY 190
2,3,3a,4-Tetraidro-1H-pirrolo[1,2-a]benzimidazol-1-oni isomeri ottenuti da 4-cloro-1,2-fenilendiamina ed acidi 3-acilpropionici 187
Identification of 2-thioxoimidazolidin-4-one derivatives as novel noncovalent proteasome and immunoproteasome inhibitors 187
3H-Azirino[1,2-d][1,4]benzodiazepin-4(5H)-ones: synthesis and stereochemistry 185
3,5-Dihydro-5-methyl-7,8-methylenedioxy-4H-2,3-benzodiazepin-4-ones as novel noncompetitive AMPA receptor antagonists 179
Constrained peptidomimetics as antiplasmodial falcipain-2 inhibitors 177
Anti-HIV agents: design and discovery of new potent RT inhibitors 172
4,4-Methylenedioxybenzene derivatives: synthesis and investigation of the mechanism of their anticonvulsant activity. 172
2,3-Benzodiazepines as potential AMPA receptors antagonists 170
Azirino[1,2-d][1,4]benzodiazepine derivatives and related 1,4- benzodiazepines as anticonvulsant agents in DBA/2 mice 170
Non-covalent immunoproteasome inhibitors induce cell cycle arrest in multiple myeloma cells 169
7,9-Dihydro-1,3-dioxolo[4,5-h][2,3]benzodiazepin-8(7H)-ones as anticonvulsant agents 168
Cross-Metathesis Reactions in the Synthesis of Constrained Dipeptide Mimics as Potent Falcipain-2 Inhibitors. 168
Design, synthesis and biological evaluation of novel dipeptide-like rhodesain inhibitors containing a conformationally constrained 3-bromoisoxazoline warhead 168
Cross-Metathesis Reactions in the Synthesis of Constrained Dipeptide Mimics as Potent Falcipain-2 Inhibitors 164
13C NMR study of tetrahydrothiazolo[3,2-d][1,4]benzodiazepin-3(2H)-ones. 163
Microwave-assisted synthesis of benzimidazole and thiazolidinone derivatives as HIV-1 RT inhibitors 161
Design and NMR conformational analysis in solution of β5i-selective inhibitors of immunoproteasome 160
Sintesi ed attività anti-HIV di 1H,3H-tiazolo[3,4-a]benzimidazoli-sostituiti 160
Development of novel 1,4-benzodiazepine-based Michael acceptors as antitrypanosomal agents 160
A simple and efficient synthesis of GYKI 52466 and GYKI 52895 159
DEVELOPMENT OF NOVEL PEPTIDOMIMETIC ANALOGUES OF A HIGHLY POTENT AND SELECTIVE FALCIPAIN-2 INHIBITOR CONTANING A VINYL ESTER MOIETY 158
Synthesis and biological evaluation of novel peptidomimetics as rhodesain inhibitors 158
Design, synthesis and molecular modeling studies on peptidomimetic vinyl esters as falcipan-2 inhibitors 157
Identification of noncovalent proteasome inhibitors with high selectivity for chymotrypsin-like activity by a multistep structure-based virtual screening 157
Anticonvulsant activity and plasma level of 2,3-benzodiazepin- 4-ones (CFMs) in genetically epilepsy-prone rats 156
6,7-Methylenedioxyphtalazin-1(2H)-ones as novel and potent anticonvulsant agents 155
Computational strategies in discovering novel non-nucleoside inhibitors of HIV-1 RT 153
Development of novel irreversible rhodesain inhibitors as antitrypanosomal agents. 153
Design, synthesis, structure-activity relationships, and molecular modeling studies of 2,3-diaryl-1,3-thiazolidin-4-ones as potent anti-HIV agents 152
Compounds with potential anti-tumor activity VII. Synthesis and anti-tumor activity of 1-aryl-N,N'-di(1,3,4-thiadiazol-2-yl)methylenediamines 151
Annelated 1,5-benzothiazepines 151
Development of novel dipeptide nitriles as inhibitors of rhodesain of Trypanosoma brucei rhodesiense 151
Development of Urea-Bond-Containing Michael Acceptors as Antitrypanosomal Agents Targeting Rhodesain 150
Development of novel amides as non covalent inhibitors of immunoproteasome 150
ANNELATED 1,5-BENZODIAZEPINES .1. 3-MEMBERED, 4-MEMBERED, AND 5-MEMBERED RINGS. 149
4,5-Methylenedioxybenzene derivatives: synthesis and investigation of the mechanism of their anticonvulsant activity. 147
6,7-Methylenedioxyquinazolin-4-ones as Anticonvulsant Agents 147
ANNELATED 1,5-BENZODIAZEPINES .2. 6 MEMBERED RINGS 147
AMINOPYRAZINYL DERIVATIVES - SYNTHESIS AND EVALUATION OF ANTIINFLAMMATORY AND RELATED ACTIVITIES 147
Development of novel benzodiazepine-based peptidomimetics as inhibitors of rhodesain of Trypanosoma brucei rhodesiense 147
Evaluation of curcumin irreversibility 146
Synthesis, Chiral Resolution and Pharmacological Evaluation of a 2,3-Benzodiazepine-Derived Noncompetitive AMPA Receptor Antagonist 145
Design and synthesis of 2,3-diaryl-1,3-thiazolidin-4one potent HIV-1 RT-inhibitors. 145
G-Protein-Coupled Receptor Kinase 2 (GRK2) Inhibitors: Current Trends and Future Perspectives 145
Falcipain-2 inhibitors 144
6,7-Methylenedioxyphthalazin-1(2H)-ones as novel and potent anticonvulsant agents 144
6,7-Metilendiossiftalazin-1(2H)-oni: una nuova classe di potenti agenti anticonvulsivanti. 143
Drug combination studies of curcumin and genistein against rhodesain of Trypanosoma brucei rhodesiense 143
ANTICONVULSANT ACTIVITY OF PYRROLO[1',2'-1,2]IMIDAZO[4,5- B]PYRIDINES, PYRROLO[2',1'-2,3]IMIDAZO[4,5-C] PYRIDINES AND PYRROLO[2,1-F]PURINES IN DBA/2 MICE 142
Immunoproteasome-selective and non-selective inhibitors: A promising approach for the treatment of multiple myeloma. 140
Development of pyridin-2-one derivatives as non-covalent inhibitors of immunoproteasome 140
Discovery of novel peptidomimetics containing a benzodiazepine scaffold as inhibitors of rhodesain of Trypanosoma brucei rhodesiense 140
Drug combination studies of isoquinolinone AM12 with curcumin or quercetin: a new combination strategy to synergistically inhibit 20S proteasome 139
Synthesis and metabolic study of 1H,3H-oxazolo[3,4-a]benzimidazoles, a new class of non-nucleoside HIV-1 RT-inhibitors. 139
Development of Novel Peptidomimetics Containing a VinylSulfone Moiety as Proteasome Inhibitors 139
Discovery of 2,3-diaryl-1,3-thiazolidin-4-ones as potent anti- HIV-1 agents 137
Synthesis and anti-HIV activity of 2,3-diaryl-1,3-thiazolidin-4-ones 137
Development of novel 1,4-benzodiazepines as antitrypanosomal agents 136
Development of novel dipeptide nitriles as inhibitors of rhodesain of Trypanosoma brucei hodesiense 136
Ciclofunzionalizzazione di 1,4- e 1,5-benzodiazepine: sintesi e stereochimica di nuovi sistemi eteropoliciclici ottenuti per reazione con acidi mercaptoacetici 135
7-Chloro-1-(2,6-difluorophenyl)-1H,3H-thiazolo[3,4- a]benzimidazole and 1-(2,6-difluorophenyl)-6-methyl-1H,3H- thiazolo[3,4-a]benzimidazole 135
Novel peptidomimetics containing different α,β-unsaturated electrophilic functions, as falcipain-2 inhibitors 135
COMPUTATIONAL APPROACHES IN DISCOVERING NOVEL ANTI-AIDS AGENTS 134
Efficient 3D Database screening for novel HIV-1 IN inhibitors 134
Immunoproteasome-selective inhibitors: a promising strategy to treat hematologic malignancies, autoimmune and inflammatory diseases 134
Synthesis and anti-HIV activity of 2,3-diaryl-1,3-thiazolidin- 4-(thi)one derivatives 133
A physico-chemical study on the interaction between papaverine and natural and modified beta-cyclodextrins 133
Anti-HIV agents .4. Synthesis and in vitro anti-HIV activity of novel 1-(2,6-difluorophenyl)-1H,3H-thiazolo[3,4- a]benzimidazoles 131
Development of isoquinolinone derivatives as immunoproteasome inhibitors. 131
An unexpected reaction between 2,3-dihydro-2,2,4-trimethyl-1H-1,5-benzodiazepine and mercaptoacetic acid 130
Development of novel N-3-bromoisoxazolin-5-yl substituted 2,3-benzodiazepines as noncompetitive AMPAR antagonists 130
Cross-metathesis reactions applications to the synthesis of peptidomimetics as potent falcipain-2 inhibitors 130
2,3-Benzodiazepine-based noncompetitive AMPAR antagonists: design, synthesis, binding affinity and mechanism of inhibition of the GluR2Qflip homomeric receptor channel 130
Optimization Strategy of Novel Peptide-Based Michael Acceptors for the Treatment of Human African Trypanosomiasis 128
Synthesis and structural features of new cyclofunctionalized benzimidazoles 127
Development of novel peptide-based Michael acceptors as antitrypanosomal agents 127
Anti-HIV agents II. Synthesis and in vitro anti-HIV activity of novel 1H,3H-thiazolo[3,4-a]benzimidazoles. 126
Design, synthesis and biological evaluation of peptidomimetics boronic acids targeting 20S proteasome 126
Blunting Neuroinflammation by Targeting the Immunoproteasome with Novel Amide Derivatives 125
Pharmacophore-Based Design of HIV-1 Integrase Strand-Transfer Inhibitors 125
Development of Novel Selective Peptidomimetics Containing a Boronic Acid Moiety, Targeting the 20S Proteasome as Anticancer Agents 124
Totale 25.374
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Categoria #
all - tutte 131.867
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 131.867
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021614 0 0 0 0 0 0 0 0 0 0 0 614
2021/20221.983 21 393 31 81 95 5 126 73 35 69 351 703
2022/20235.506 436 434 232 440 443 591 131 323 2.206 20 181 69
2023/20241.223 138 189 87 267 123 122 21 47 6 85 49 89
2024/20255.685 113 76 136 430 234 102 101 1.258 1.525 285 457 968
2025/202625.495 635 3.566 7.543 1.343 1.301 4.004 2.135 1.999 1.925 588 258 198
Totale 46.736