Evaluation Of Cisplatin Plasma Levels In Patients Undergoing Cytoreductive Surgery And Hyperthermic Intraperitoneal Chemotherapy.

Introduction: Peritoneal surface malignancies have long been regarded as incurable, however they can be treated with cytoreductive surgery in addition to hyperthermic intraperitoneal chemotherapy. This approach is associated with an increase in morbidity and mortality, unless hyperhydration is provided in a timely manner. Methods: Cisplatin (CDDP) is the most widely used chemotherapeutic agent. Plasma levels of cisplatin (CDDP), a widely used chemotherapeutic agent, were measured before, during and after the procedure. This was done in order to identify the window of highest risk as a function of drug concentrations, assuming a dose-dependent effect. Results: Plasma levels of CDDP peak during perfusion. The concentration remains high until the 4th post-operative day and returns to pre-operative levels by the 7th post-operative day. Conclusions: Our findings suggest that ensuring hyperydration as well as infusing albumin and fresh frozen plasma may be of particular value for at least the first 4 days after the procedure.